Evidence map›Paper›PMID 9038634›Full record

ReviewGenitourinary medicine1996

The role of vaccines in the control of STDs: HPV vaccines.

I H Frazer

Open access · bronzeAbstract readReview
In one paragraph

Review in Genitourinary medicine, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

I H FrazerDepartment of Medicine, Princess, Alexandra Hospital, Woolloongabba, Queensland, Australia.
Princess Alexandra Hospital · AU

Funding

ANIMAL MODELS TO TEST VACCINES FOR CERVICAL CANCERR01CA057789 · NCI · QUEENSLAND UNIVERSITY OF TECHNOLOGY · PI FRAZER, IAN H · 1992 to 1994
–
NCI NIH HHS R01-CA-57789-03
6 · The paper itself

Abstract

Prophylactic vaccines for genital human papillomavirus (HPV) infection have been shown to be feasible in animal models, and suitable vaccine material based on virus-like particles can be produced in bulk at reasonable cost. Initiation of phase III clinical trials will follow definition of trial outcome measures through further epidemiological studies, and development of assays of host protective immunity. Vaccines could in principle eliminate HPV-related disease, as the human race is the only natural host for the relevant papillomaviruses (PVs). Therapeutic vaccines for genital HPV infection are also possible, but have not yet been demonstrated as feasible in practice because the choice of vaccine antigens is difficult, the method of their optimal delivery is uncertain, and the nature of the relevant antiviral immunity is unknown. PV species specificity will require trials to be conducted in man, which will slow definition of an ideal vaccine.

Indexed as

PapillomaviridaePapillomavirus VaccinesViral VaccinesAdultAnimalsCattleClinical Trials, Phase I as TopicCondylomata AcuminataDogsFemaleGlobal HealthHumansMaleMiddle AgedRabbitsTumor Virus InfectionsPapillomavirus VaccinesViral Vaccines

Identifiers

PMID9038634
PMCPMC1195726
OpenAlexW2171418468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.