ArticleInfection and immunity1997
Innate immunity to Toxoplasma gondii is influenced by gender and is associated with differences in interleukin-12 and gamma interferon production.
Article in Infection and immunity, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 84 citations in OpenAlex.
- Special Issue: Does latent Toxoplasma infection mimic the immune profile of schizophrenia? Sex-specific cytokine and brain-marker alterations suggest partial overlap.Folia parasitologica · 2026Article
- Possible association between Toxoplasma gondii infection and autism spectrum disorder.Parasites, hosts and diseases · 2025Review
- Seroprevalence and molecular detection of Toxoplasma gondii and Neospora caninum in beef cattle and goats in Hunan province, China.Parasites & vectors · 2024Article
- A Review ofAnimals : an open access journal from MDPI · 2023Review
- The Impact of Estrogens and Their Receptors on Immunity and Inflammation during Infection.Cancers · 2022Review
- Effect of 17β-Estradiol, Progesterone, and Tamoxifen on Neurons Infected withMicroorganisms · 2021Article
- An Exaggerated Immune Response in Female BALB/c Mice Controls InitialPathogens (Basel, Switzerland) · 2021Article
- Rat volatiles as an attractant source for the Asian tiger mosquito, Aedes albopictus.Scientific reports · 2020Article
- Review
- Sex Steroids Mediate Bidirectional Interactions Between Hosts and Microbes.Hormones and behavior · 2017Review
- Experimental infection of Calomys callosus with atypical strains of Toxoplasma gondii shows gender differences in severity of infection.Parasitology research · 2014Article
- Spinal cord pathology in chronic experimental Toxoplasma gondii infection.European journal of microbiology & immunology · 2014Article
- Effect of sex steroids on Babesia microti infection in mice.The American journal of tropical medicine and hygiene · 2013Article
- The interleukin-17 receptor plays a gender-dependent role in host protection against Porphyromonas gingivalis-induced periodontal bone loss.Infection and immunity · 2008Article
- Sexual dimorphism in immune response genes as a function of puberty.BMC immunology · 2006Article
- Sexual dimorphism in the control of amebic liver abscess in a mouse model of disease.Infection and immunity · 2006Article
- Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cells.Infection and immunity · 2005Article
- Sex-dependent susceptibility to Listeria monocytogenes infection is mediated by differential interleukin-10 production.Infection and immunity · 2005Article
- Evidence for a perforin-mediated mechanism controlling cardiac inflammation in Trypanosoma cruzi infection.International journal of experimental pathology · 2002Article
- Innate resistance to Babesia infection is influenced by genetic background and gender.Infection and immunity · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given that differences between the sexes in relative susceptibility to parasitic infections have been noted, this study further elucidates the mechanisms responsible by demonstrating that male SCID mice are more resistant than female mice to infection with Toxoplasma gondii and that this difference correlates with enhanced innate immune responses in these animals. Male SCID mice exhibited longer survival times, lower parasite burdens, and less severe pathological changes postinfection. An immunological basis for these differences is demonstrated in that these animals produced interleukin-12 more rapidly and exhibited higher levels of gamma interferon earlier postinfection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.