ArticleVirchows Archiv : an international journal of pathology1997
E-cadherin (E-cad) expression in duct carcinoma in situ (DCIS) of the breast.
Article in Virchows Archiv : an international journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 63 citations in OpenAlex.
- Investigating the interplay between the mir-183/182/96 cluster and the adherens junction pathway in early-stage breast cancer.Scientific reports · 2024Article
- Lobular carcinoma in situ: diagnostic criteria and molecular correlates.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021Review
- Precursors and preinvasive lesions of the breast: the role of molecular prognostic markers in the diagnostic and therapeutic dilemma.World journal of surgical oncology · 2007Review
- Roles of the transcription factors snail and slug during mammary morphogenesis and breast carcinoma progression.Journal of mammary gland biology and neoplasia · 2004Review
- Ionizing radiation induces heritable disruption of epithelial cell interactions.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- E-cadherin as a prognostic indicator in primary breast cancer.British journal of cancer · 2001Article
- Cadherin junctions in mammary tumors.Journal of mammary gland biology and neoplasia · 2001Review
- Regulation of E-cadherin: does hypoxia initiate the metastatic cascade?Molecular pathology : MP · 1999Review
- Evidence of significant apoptosis in poorly differentiated ductal carcinoma in situ of the breast.British journal of cancer · 1998Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
E-cadherin (E-cad) is an epithelial cell-cell adhesion molecule whose loss or reduced expression is associated with a more invasive tumour phenotype. Ninety-six cases of screen detected pure ductal carcinoma in situ (DCIS) were analysed immunocytochemically for expression of E-cad using the HECD-1 mouse monoclonal antibody. The in situ component in each case was classified on the basis of cytonuclear grade, extent of necrosis, Van Nuys classification and a newly devised Cardiff classification. The amount of E-cad expression was assessed semi-quantitatively using an intensity distribution method. There is significantly more expression of E-cad in well-differentiated DCIS when compared with poorly differentiated DCIS and this finding is highly significant (P < 0.001) irrespective of the classification system used. These findings suggest that progressive loss of E-cad expression may occur at an early stage of breast cancer development.
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