ArticleProceedings of the National Academy of Sciences of the United States of America1997
A complex major histocompatibility complex D locus variant generated by an unusual recombination mechanism in mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 14 citations in OpenAlex.
- Concerted and birth-and-death evolution of multigene families.Annual review of genetics · 2005Review
- Frequent segmental sequence exchanges and rapid gene duplication characterize the MHC class I genes in lemurs.Immunogenetics · 2003Article
- Discrimination of MHC-derived odors by untrained mice is consistent with divergence in peptide-binding region residues.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Evolution by the birth-and-death process in multigene families of the vertebrate immune system.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
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3 authors at 1 institution in 1 country.
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Abstract
A spontaneous variant of the mouse class I major histocompatibility complex D(b) gene, designated D(bm28), is characterized. This mutation consists of a cluster of nucleotide substitutions in exon 3 that resembles the product of a classical gene conversion event in that the substituted nucleotides appear to be templated. However, D(bm28) is distinctive, because no single donor gene containing the nucleotide sequence of the mutation exists in the genome of the parent strain. The mutation is consistent with the expected result of an interaction of two donor genes at the target locus during a single recombination event. While no known genetic mechanism gives rise to this class of mutation, we have established that 10 percent of spontaneous class I mutations in the mouse major histocompatibility complex have this complex phenotype. This process occurs at the D locus and the K locus. The significance of this kind of genetic interaction may extend beyond the major histocompatibility complex and have importance in shaping other multigene families.
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