ArticleProceedings of the National Academy of Sciences of the United States of America1997
Highly purified CD25- resting T cells cannot be infected de novo with HIV-1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 105 citations in OpenAlex.
- HIV specific Th1 responses are altered in Ugandans with HIV and Schistosoma mansoni coinfection.BMC immunology · 2023Article
- CD25+ FoxP3+ Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo.Journal of virology · 2016Article
- HIV Susceptibility of human antigen-specific CD4 T cells in AIDS pathogenesis and vaccine response.Expert review of vaccines · 2016Review
- Sequential Dysfunction and Progressive Depletion of Candida albicans-Specific CD4 T Cell Response in HIV-1 Infection.PLoS pathogens · 2016Article
- Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- HIV restriction in quiescent CD4⁺ T cells.Retrovirology · 2013Review
- Article
- HIV pathogenesis: the host.Cold Spring Harbor perspectives in medicine · 2012Review
- Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection.Trends in immunology · 2012Article
- De novo generation of cells within human nurse macrophages and consequences following HIV-1 infection.PloS one · 2012Article
- Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection.The Journal of experimental medicine · 2010Article
- Quiescent T cells and HIV: an unresolved relationship.Immunologic research · 2010Review
- Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs.Nature reviews. Microbiology · 2009Review
- The gastrointestinal tract and AIDS pathogenesis.Gastroenterology · 2009Review
- Comparison of plasma viremia and antibody responses in macaques inoculated with envelope variants of single-cycle simian immunodeficiency virus differing in infectivity and cellular tropism.Journal of virology · 2008Article
- Centrosomal pre-integration latency of HIV-1 in quiescent cells.Retrovirology · 2007Article
- Glucocorticoid-induced tumor necrosis factor receptor family-related protein triggering enhances HIV-specific CD4+ T cell cytokine secretion and protects HIV-specific CD4+ T cells from apoptosis.The Journal of infectious diseases · 2007Article
- Centrosomal latency of incoming foamy viruses in resting cells.PLoS pathogens · 2007Article
- Immediate activation fails to rescue efficient human immunodeficiency virus replication in quiescent CD4+ T cells.Journal of virology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have demonstrated that the expression of CD25 can distinguish CD25- latently infected cells from CD25+ cells actively producing virus. Our studies were designed to characterize the nature and stability of the viral genome in CD25- quiescent HIV-1-infected cells and to determine whether these cells could be infected de novo with HIV-1. Our results show that: (i) When unfractionated peripheral blood mononuclear cells are first infected with HIV-1 and the CD25- cells then isolated, the latter contain only incomplete DNA transcripts and no full-length DNA or 2-LTR circles. Phytohemagglutinin activation of these CD25- cells results in the generation of full-length viral DNA and p24 production. (ii) When CD25- CD4+ cells are first purified from peripheral blood mononuclear cells and then incubated with HIV-1, viral DNA cannot be detected, suggesting that these purified cells cannot be infected. Furthermore, CD25-adherent cells do not facilitate the infection of CD4+ CD25- T cells when they were present at the time of incubation with HIV-1. Taken together, these studies suggest either that (i) the CD25- cells containing incomplete DNA transcripts are derived from infected-activated CD25+ cells, which subsequently become CD25- or (ii) the presence of CD25+ cells is required for the infection of CD25- cells in vitro.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.