ArticleProceedings of the National Academy of Sciences of the United States of America1997
Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 133 citations in OpenAlex.
- Sex Differences in Lung B Cell Responses in a Murine Model of Asthma.International archives of allergy and immunology · 2026Article
- A current review on animal models of anti-asthmatic drugs screening.Frontiers in pharmacology · 2025Review
- Natural antibodies drive type 2 immunity in response to damage-associated molecular patterns.JCI insight · 2024Article
- Regulatory B cells in respiratory health and diseases.Immunological reviews · 2021Review
- Isolated Schistosoma mansoni eggs prevent allergic airway inflammation.Parasite immunology · 2018Article
- House Dust Mite-Induced Allergic Airway Disease Is Independent of IgE and FcεRIα.American journal of respiratory cell and molecular biology · 2017Article
- CD4⁺ and CD8⁺ T cells play a central role in a HDM driven model of allergic asthma.Respiratory research · 2016Article
- Hyaluronan stimulates ex vivo B lymphocyte chemotaxis and cytokine production in a murine model of fungal allergic asthma.Immunobiology · 2015Article
- B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma.Cellular & molecular immunology · 2015Article
- B cells play key roles in th2-type airway immune responses in mice exposed to natural airborne allergens.PloS one · 2015Article
- Lymphocyte-based model systems for allergy research: a historic overview.International archives of allergy and immunology · 2014Review
- μ-chain-deficient mice possess B-1 cells and produce IgG and IgE, but not IgA, following systemic sensitization and inhalational challenge in a fungal asthma model.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Effects of systemic versus local administration of corticosteroids on mucosal tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Treatment of cocaine abuse during pregnancy: translating research to clinical practice.Current psychiatry reports · 2010Review
- Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice.The European respiratory journal · 2010Article
- Similar response in male and female B10.RIII mice in a murine model of allergic airway inflammation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Breastmilk from allergic mothers can protect offspring from allergic airway inflammation.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2009Article
- Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cells.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Gender comparison in a murine model of allergen-driven airway inflammation and the response to budesonide treatment.BMC pharmacology · 2004Article
- Chronic inhaled ovalbumin exposure induces antigen-dependent but not antigen-specific inhalational tolerance in a murine model of allergic airway disease.The American journal of pathology · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
B cells play an important role in the allergic response by producing allergen-specific Igs as well as by serving as antigen-presenting cells. We studied the involvement of B cells in the development of responses in a murine model of allergic airway sensitization. Normal and B cell-deficient (muMt-/-) B10.BR mice were sensitized via the airways to ovalbumin; Ig production, cytokine elaboration from local lymph node cells, development of airway hyperresponsiveness, and histological changes in the airways were evaluated. Both strains of mice had increased production of T helper 2-like cytokines and developed an accumulation of eosinophils in the bronchial tissue after airway sensitization. However, only wild-type mice produced allergen-specific antibodies and exhibited altered airway function. B cell-deficient mice reconstituted with anti-ovalbumin IgE during the course of sensitization developed increases in airway responsiveness. These results indicated that neither B cells nor IgE were necessary for the induction of a T helper 2-type cytokine response or eosinophil infiltration of the airways after allergic sensitization but that IgE was required as a second signal for the development of airway hyperresponsiveness in this model of airway sensitization.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.