ArticleProceedings of the National Academy of Sciences of the United States of America1997
Evidence for a role for DNA polymerase beta in mammalian meiosis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Mouse models to explore the biological and organismic role of DNA polymerase beta.Environmental and molecular mutagenesis · 2024Review
- PEX10, SIRPA-SIRPG, and SOX5 gene polymorphisms are strongly associated with nonobstructive azoospermia susceptibility.Journal of assisted reproduction and genetics · 2019Article
- Eukaryotic DNA Polymerases in Homologous Recombination.Annual review of genetics · 2016Review
- Protein Arginine Methyltransferase 6 Involved in Germ Cell Viability during Spermatogenesis and Down-Regulated by the Androgen Receptor.International journal of molecular sciences · 2015Article
- Meiotic Recombination: The Essence of Heredity.Cold Spring Harbor perspectives in biology · 2015Review
- Cellular roles of DNA polymerase beta.The Yale journal of biology and medicine · 2013Review
- Clamping down on mammalian meiosis.Cell cycle (Georgetown, Tex.) · 2013Article
- Article
- Potential role of meiosis proteins in melanoma chromosomal instability.Journal of skin cancer · 2013Article
- A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.Nature genetics · 2011Article
- A triad interaction in the fingers subdomain of DNA polymerase beta controls polymerase activity.Journal of the American Chemical Society · 2011Article
- DNA polymerase beta is critical for mouse meiotic synapsis.The EMBO journal · 2010Article
- The Asp285 variant of DNA polymerase beta extends mispaired primer termini via increased nucleotide binding.Biochemistry · 2008Article
- Correlation of meiotic events in testis sections and microspreads of mouse spermatocytes relative to the mid-pachytene checkpoint.Chromosoma · 2004Article
- Characterization of a mouse recombination hot spot locus encoding a novel non-protein-coding RNA.Molecular and cellular biology · 2004Article
- Article
- Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice.Genes & development · 2003Article
- p53 mutated in the transactivation domain retains regulatory functions in homology-directed double-strand break repair.Oncogene · 2003Article
- DNA substrate dependence of p53-mediated regulation of double-strand break repair.Molecular and cellular biology · 2002Article
- Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase lambda-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome.Molecular and cellular biology · 2002Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
DNA polymerase beta (pol beta) is an enzyme possessing both polymerase and deoxyribose phophatase activities. Although pol beta is not believed to participate in the replication of genomic DNA, several studies have indicated a role for pol beta in DNA repair. The high level of expression of pol beta in mouse and rat testes raises the possibility that pol beta participates in mammalian meiosis. Using antibody localization, we detect foci that stain with pol beta antisera at discrete sites along homologous chromosomes as they synapse and progress through prophase of meiosis I. These data suggest that pol beta participates in meiotic events associated with synapsis and recombination.
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Registered trials
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