ReviewCancer metastasis reviews1996
Implications of intermediate filament protein phosphorylation.
Review in Cancer metastasis reviews, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- A study of the phosphorylation proteomic skin characteristics of Tan sheep during the newborn and er-mao stages.Tropical animal health and production · 2021Article
- Quantitative Phosphoproteomic Comparison of Lens Proteins in Highly Myopic Cataract and Age-Related Cataract.BioMed research international · 2021Article
- Variation in the Caprine Keratin-Associated Protein 27-1 Gene is Associated with Cashmere Fiber Diameter.Genes · 2020Article
- Article
- Identification of CaprineGenes · 2020Article
- Variation in the Caprine KAP24-1 Gene Affects Cashmere Fibre Diameter.Animals : an open access journal from MDPI · 2019Article
- Article
- GFAP isoforms control intermediate filament network dynamics, cell morphology, and focal adhesions.Cellular and molecular life sciences : CMLS · 2016Article
- Comprehensive maternal serum proteomics identifies the cytoskeletal proteins as non-invasive biomarkers in prenatal diagnosis of congenital heart defects.Scientific reports · 2016Article
- Article
- Increased Phospho-Keratin 8 Isoforms in Colorectal Tumors Associated with EGFR Pathway Activation and Reduced Apoptosis.ISRN molecular biology · 2012Article
- Identification of the ovine KAP11-1 gene (KRTAP11-1) and genetic variation in its coding sequence.Molecular biology reports · 2011Article
- Vimentin in cancer and its potential as a molecular target for cancer therapy.Cellular and molecular life sciences : CMLS · 2011Review
- Article
- Keratin 18 phosphorylation as a progression marker of chronic hepatitis B.Virology journal · 2010Article
- Posttranslational modifications of the bovine lens beaded filament proteins filensin and CP49.Investigative ophthalmology & visual science · 2010Article
- Immunolocalization of fascin, an actin-bundling protein and glial fibrillary acidic protein in human astrocytoma cells.Brain pathology (Zurich, Switzerland) · 2010Article
- Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta.Molecular biology of the cell · 2009Article
- Structure and functions of keratin proteins in simple, stratified, keratinized and cornified epithelia.Journal of anatomy · 2009Review
- Identification of phosphorylation-induced changes in vimentin intermediate filaments by site-directed spin labeling and electron paramagnetic resonance.Biochemistry · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Intermediate filament (IF) proteins, a large family of tissue specific proteins, undergo several posttranslational modifications, with phosphorylation being the most studied modification. IF protein phosphorylation is highly dynamic and involves the head and/or tail domains of these proteins, which are the domains that impart most of the structural heterogeneity and hence presumed tissue specific functions. Although the function of IF proteins remains poorly understood, several regulatory roles for IF protein phosphorylation have been identified or are emerging. Those roles include filament disassembly and reorganization, solubility, localization within specific cellular domains, association with other cytoplasmic or membrane associated proteins, protection against physiologic stress and mediation of tissue-specific functions. Understanding the mechanistic and functional aspects of IF protein phosphorylation is providing insights not only regarding the function of this modification, but also regarding the function of IF proteins.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.