ArticleThe Journal of experimental medicine1997
Induction of the early growth response (Egr) family of transcription factors during thymic selection.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 141 citations in OpenAlex.
- IL-2/CD25 acts within the tumor microenvironment to reprogram tumor-specific cytotoxic CD8Journal for immunotherapy of cancer · 2026Article
- SATB1 lowers the T cell receptor signaling threshold for thymocyte positive selection via super-enhancer reprogramming.Nature communications · 2026Article
- Review
- A convenient single-cell assay for the newly synthesized transcriptome reveals FLI1 regulon downregulation during T cell activation.Cell reports methods · 2026Article
- Th1-poised naive CD4 T cell subpopulation reflects anti-tumor immunity and autoimmune disease.Nature communications · 2025Article
- Cytotoxic T lymphocytes require transcription for infiltration but not target cell lysis.EMBO reports · 2023Article
- Larval T Cells Are Functionally Distinct from Adult T Cells in Xenopus laevis.ImmunoHorizons · 2023Article
- Single-cell multiomic analysis of thymocyte development reveals drivers of CD4Nature immunology · 2023Article
- Transcription factor EGR2 controls homing and pathogenicity of TNature immunology · 2023Article
- Altered thymocyte development observed in EphA4-deficient mice courses with changes in both thymic epithelial and extracellular matrix organization.Cellular and molecular life sciences : CMLS · 2022Article
- Calcium signals regulate the functional differentiation of thymic iNKT cells.The EMBO journal · 2021Article
- Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- miR-21 sustains CD28 signalling and low-affinity T-cell responses at the expense of self-tolerance.Clinical & translational immunology · 2021Article
- An Integrated Epigenomic and Transcriptomic Map of Mouse and Human αβ T Cell Development.Immunity · 2020Article
- Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells.Haematologica · 2020Article
- TCR signal strength controls thymic differentiation of iNKT cell subsets.Nature communications · 2018Article
- Nab2 maintains thymus cellularity with aging and stress.Molecular immunology · 2017Article
- Pak2 Controls Acquisition of NKT Cell Fate by Regulating Expression of the Transcription Factors PLZF and Egr2.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- A Zap70-dependent feedback circuit is essential for efficient selection of CD4 lineage thymocytes.Immunology and cell biology · 2015Article
- Overlapping and asymmetric functions of TCR signaling during thymic selection of CD4 and CD8 lineages.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
There is little known about the regulation of gene expression during TCR-mediated differentiation of immature CD4+8+ (double positive) thymocytes into mature T cells. Using the DPK CD4+8+ thymocyte precursor cell line, we demonstrate that the early growth response-1 gene (Erg-1), encoding a zinc finger transcription factor, is rapidly upregulated after TCR stimulation. We also report that Egr-1 is expressed by a subset of normal double positive thymocytes in the thymic cortex, as well by a majority of medullary single positive thymocytes. Expression of Egr-1 is dramatically reduced in the thymus of major histocompatibility complex knockout mice, but can be induced by anti-CD3 antibody stimulation of isolated thymocytes from these animals. These and other data suggest that high level expression of Egr-1 in the thymus is a consequence of selection. A similar pattern of expression is found for family members Egr-2 and Egr-3. Using the DPK cell line, we also demonstrate that expression of Egr-1, 2, and 3 is dependent upon ras activation, as is the initiation of differentiation to a single positive cell. In contrast, the calcineurin inhibitor cyclosporin A, which inhibits DPK cell differentiation as well as positive selection, inhibits expression of Egr-2 and Egr-3, but not Egr-1. The identification of the Egr family in this context represents the first report of a link between the two known signaling pathways involved in positive selection and downstream transcriptional regulators.
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