ArticleThe Journal of experimental medicine1997
Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 205 citations in OpenAlex.
- Influence of Self-MHC Class I Recognition on the Dynamics of NK Cell Responses to Cytomegalovirus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Genetic manipulation of primary human natural killer cells to investigate the functional and oncogenic roles of PRDM1.Haematologica · 2021Article
- Licensing Natural Killers for Antiviral Immunity.Pathogens (Basel, Switzerland) · 2021Review
- Natural Killer Cells: Tumor Surveillance and Signaling.Cancers · 2020Review
- The Protein Phosphatase Shp1 Regulates Invariant NKT Cell Effector Differentiation Independently of TCR and Slam Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- The Role of Adaptor Proteins in the Biology of Natural Killer T (NKT) Cells.Frontiers in immunology · 2019Review
- Protein Tyrosine Phosphatases: Regulators of CD4 T Cells in Inflammatory Bowel Disease.Frontiers in immunology · 2018Review
- Immunoreceptor tyrosine-based inhibitory motif-dependent functions of an MHC class I-specific NK cell receptor.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- The activating Ly49W and inhibitory Ly49G NK cell receptors display similar affinities for identical MHC class I ligands.Immunogenetics · 2014Article
- Interferon response factor 3 is crucial to poly-I:C induced NK cell activity and control of B16 melanoma growth.Cancer letters · 2014Article
- The early days of NK cells: an example of how a phenomenon led to detection of a novel immune receptor system - lessons from a rat model.Frontiers in immunology · 2014Review
- Ly49 receptors: innate and adaptive immune paradigms.Frontiers in immunology · 2014Review
- Shp1 regulates T cell homeostasis by limiting IL-4 signals.The Journal of experimental medicine · 2013Article
- SHP-1 phosphatase is a critical regulator in preventing natural killer cell self-killing.PloS one · 2012Article
- 'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection.Nature immunology · 2010Article
- Effects of MHC class I alleles on licensing of Ly49A+ NK cells.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis.Immunity · 2009Article
- Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.The Journal of experimental medicine · 2008Article
- Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome.Genes and immunity · 2008Article
- The balancing act: inhibitory Ly49 regulate NKG2D-mediated NK cell functions.Seminars in immunology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The lytic activity of natural killer (NK) cells is inhibited by the expression of class I major histocompatibility complex (MHC) antigens on target cells. In murine NK cells, Ly-49A mediates inhibition of cytotoxicity in response to the class I MHC antigen H-2Dd. In this report, we studied the function of mouse Ly-49A in both the rat NK cell tumor line, RNK-16, transfected with Ly-49A cDNA, and in primary NK cells. We show that ligation of Ly-49A by H-2Dd inhibits early signaling events during target cell stimulation, including polyphosphoinositide turnover and tyrosine phosphorylation. We also show that Ly-49A directly associates with the cytoplasmic tyrosine phosphatase SHP-1, and that Ly-49A function is impaired in NK cells from SHP-1 mutant viable motheaten mice and from SHP-1-deficient motheaten mice. Finally, we demonstrate that mutational substitution of the tyrosine within the proposed SHP-1 binding motif in Ly-49A completely abrogates inhibition of NK cell cytotoxicity through this receptor. These results demonstrate that Ly-49A interrupts early activating signals in NK cells, and that SHP-1 is an important mediator of Ly-49A function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.