ArticleThe Journal of experimental medicine1997
A transgenic marker for mouse B lymphoid precursors.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
- Terminal deoxynucleotidyl transferase and CD84 identify human multi-potent lymphoid progenitors.Nature communications · 2024Article
- Dissection of progenitor compartments resolves developmental trajectories in B-lymphopoiesis.The Journal of experimental medicine · 2018Article
- Molecular Regulation of Differentiation in Early B-Lymphocyte Development.International journal of molecular sciences · 2018Review
- Deregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice.Disease models & mechanisms · 2016Article
- Early B-cell factor 1 regulates the expansion of B-cell progenitors in a dose-dependent manner.The Journal of biological chemistry · 2013Article
- Separation of plasmacytoid dendritic cells from B-cell-biased lymphoid progenitor (BLP) and Pre-pro B cells using PDCA-1.PloS one · 2013Article
- Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis.The Journal of experimental medicine · 2008Article
- Lineage specification and plasticity in CD19- early B cell precursors.The Journal of experimental medicine · 2006Article
- Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain components.The Journal of experimental medicine · 2004Article
- The oncoprotein MLL-ENL disturbs hematopoietic lineage determination and transforms a biphenotypic lymphoid/myeloid cell.Oncogene · 2003Article
- The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes.The Journal of experimental medicine · 2001Article
- Loss of precursor B cell expansion but not allelic exclusion in VpreB1/VpreB2 double-deficient mice.The Journal of experimental medicine · 2001Article
- Review article: role of the surrogate light chain and the pre-B-cell receptor in mouse B-cell development.Immunology · 2000Review
- Overlapping expression of early B-cell factor and basic helix-loop-helix proteins as a mechanism to dictate B-lineage-specific activity of the lambda5 promoter.Molecular and cellular biology · 2000Article
- Analysis of mice with single and multiple copies of transgenes reveals a novel arrangement for the lambda5-VpreB1 locus control region.Molecular and cellular biology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three lines of transgenic mice have been generated which express human CD25 under the control of the 722-base pair region located immediately 5' of the precursor (pre)-B cell-specific lambda5 gene. All three strains express human CD25 in parallel to endogenous lambda5 on pre-B cells, but not on mature B lymphocytes or other blood cell lineages. High expression of human CD25 on B lineage cells of transgenic mice has allowed the identification of a new B220+CD19-lambda5+ precursor of the B220+CD19+lambda5+ c-kit+ pre-BI cells. Both types of precursors are clonable on stromal cells in the presence of interleukin-7. The CD19- precursors have a sizeable part of their immunoglobulin heavy chain gene loci in germline configuration, while the CD19+ pre-BI cells are predominantly DJH rearranged. The results indicate that random integration of the 722-bp 5' region of the lambda5 gene into the mouse genome confers tissue and differentiation stage-specific expression of a transgene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.