ArticleThe Journal of experimental medicine1997
Changes in locus-specific V(D)J recombinase activity induced by immunoglobulin gene products during B cell development.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 113 citations in OpenAlex.
- The Role of DNA Repair in Genomic Instability of Multiple Myeloma.International journal of molecular sciences · 2022Review
- Immune Gene Rearrangements: Unique Signatures for Tracing Physiological Lymphocytes and Leukemic Cells.Genes · 2021Review
- Epigenetic Enhancer Marks and Transcription Factor Binding Influence Vκ Gene Rearrangement in Pre-B Cells and Pro-B Cells.Frontiers in immunology · 2018Article
- Mechanisms of central tolerance for B cells.Nature reviews. Immunology · 2017Review
- A novel pax5-binding regulatory element in the igκ locus.Frontiers in immunology · 2014Article
- Immunology: B-cell development in the gut.Nature · 2013Article
- Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Article
- Epigenetic control of recombination in the immune system.Seminars in immunology · 2010Review
- Allelic exclusion of immunoglobulin genes: models and mechanisms.Immunological reviews · 2010Review
- Development of immunoglobulin lambda-chain-positive B cells, but not editing of immunoglobulin kappa-chain, depends on NF-kappaB signals.Nature immunology · 2009Article
- Two distinct populations of H chain-edited B cells show differential surrogate L chain dependence.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination.Nucleic acids research · 2008Article
- Chromosomal position of a VH gene segment determines its activation and inactivation as a substrate for V(D)J recombination.The Journal of experimental medicine · 2007Article
- Basal immunoglobulin signaling actively maintains developmental stage in immature B cells.PLoS biology · 2005Article
- Locus 'decontraction' and centromeric recruitment contribute to allelic exclusion of the immunoglobulin heavy-chain gene.Nature immunology · 2005Article
- Changes in histone acetylation are associated with differences in accessibility of V(H) gene segments to V-DJ recombination during B-cell ontogeny and development.Molecular and cellular biology · 2003Article
- Localized gene-specific induction of accessibility to V(D)J recombination induced by E2A and early B cell factor in nonlymphoid cells.The Journal of experimental medicine · 2001Article
- Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse.The Journal of experimental medicine · 2001Article
- Induction of pre-B cell proliferation after de novo synthesis of the pre-B cell receptor.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The process of V(D)J recombination is crucial for regulating the development of B cells and for determining their eventual antigen specificity. Here we assess the developmental regulation of the V(D)J recombinase directly, by monitoring the double-stranded DNA breaks produced in the process of V(D)J recombination. This analysis provides a measure of recombinase activity at immunoglobulin heavy and light chain loci across defined developmental stages spanning the process of B cell development. We find that expression of a complete immunoglobulin heavy chain protein is accompanied by a drastic change in the targeting of V(D)J recombinase activity, from being predominantly active at the heavy chain locus in pro-B cells to being exclusively restricted to the light chain loci in pre-B cells. This switch in locus-specific recombinase activity results in allelic exclusion at the immunoglobulin heavy chain locus. Allelic exclusion is maintained by a different mechanism at the light chain locus. We find that immature, but not mature, B cells that already express a functional light chain protein can undergo continued light chain gene rearrangement, by replacement of the original rearrangement on the same allele. Finally, we find that the developmentally regulated targeting of V(D)J recombination is unaffected by enforced rapid transit through the cell cycle induced by an E mu-myc transgene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.