ArticleThe American journal of pathology1997
Lysyl oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma.
Article in The American journal of pathology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 122 citations in OpenAlex.
- Article
- Expression of amine oxidase-related proteins in breast phyllodes tumor.Histology and histopathology · 2025Article
- The role of matrix stiffness in breast cancer progression: a review.Frontiers in oncology · 2023Review
- A miniaturized screening platform to identify novel regulators of extracellular matrix alignment.Cancer research communications · 2022Article
- Stromal Characteristics and Impact on New Therapies for Metastatic Triple-Negative Breast Cancer.Cancers · 2022Review
- Review
- Tumor Microenvironment in Breast Cancer-Updates on Therapeutic Implications and Pathologic Assessment.Cancers · 2021Review
- Towards extracellular matrix normalization for improved treatment of solid tumors.Theranostics · 2020Review
- Perturbed myoepithelial cell differentiation in BRCA mutation carriers and in ductal carcinoma in situ.Nature communications · 2019Article
- Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy.Frontiers in molecular biosciences · 2019Review
- Restriction of drug transport by the tumor environment.Histochemistry and cell biology · 2018Review
- Targeted matrisome analysis identifies thrombospondin-2 and tenascin-C in aligned collagen stroma from invasive breast carcinoma.Scientific reports · 2018Article
- Preclinical ex vivo evaluation of the diagnostic performance of a new device for in situ label-free fluorescence spectral analysis of breast masses.European radiology · 2018Article
- Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer.BMC urology · 2017Article
- Human colorectal cancer progression correlates with LOX-induced ECM stiffening.International journal of biological sciences · 2017Article
- P-selectin-mediated LOX expression promotes insulinoma growth in Rip1-Tag2 mice by increasing tissue stiffness.International journal of biological sciences · 2016Article
- Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer.Trends in biotechnology · 2015Review
- NNK, a tobacco-specific carcinogen, inhibits the expression of lysyl oxidase, a tumor suppressor.International journal of environmental research and public health · 2014Article
- Integrins in development and cancer.Biophysical reviews · 2014Review
- Epistemology of the origin of cancer: a new paradigm.BMC cancer · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lysyl oxidase is involved in the main pathway of collagen and elastin cross-linking: it has a role in the maturation of fibrillar matrix proteins in fibrosing processes and dictates their stability against metalloproteases. The stromal reaction patterns in ductal breast carcinoma are known to be morphologically varied. This has raised the hypothesis that there might be a differential expression of the lysyl oxidase gene as a function of stromal reaction pattern. The present study investigates this potential correlation and the role of matrix protein cross-linking in stromal differentiation. Lysyl oxidase was detected by immunohistochemistry and lysyl oxidase gene expression by in situ hybridization. Maximal expression was observed in myofibroblasts and myoepithelial cells around in situ tumors and in the reactive fibrosis facing the invasion front of infiltrating tumors. The lysyl oxidase substrates were observed in parallel, resulting in the stabilization of a scar-like peritumor barrier. In contrast, a lack of lysyl oxidase was associated with the loose or scirrhous stroma accompanying invading tumors; here, in situ hybridization revealed type I collagen synthesis, resulting in the deposition of non-cross-linked matrix proteins susceptible to degradation. The early development of a cross-linked matrix around ductal breast carcinoma suggests a possible bost defense mechanism, whereas the synchronous or late stromal reaction lacking lysyl oxidase favors tumor dispersion.
Indexed as
Identifiers
9033266PMC1858268W144100097What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.