ArticleThe Journal of physiology1997
Myogenic contraction by modulation of voltage-dependent calcium currents in isolated rat cerebral arteries.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 96 citations in OpenAlex.
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- Increased uterine arterial tone, stiffness and remodeling with augmented matrix metalloproteinase-1 and -7 in uteroplacental ischemia-induced hypertensive pregnancy.Biochemical pharmacology · 2024Article
- Increased CaBiochemical pharmacology · 2023Article
- Inositol 1,4,5-Trisphosphate Receptors in Hypertension.Frontiers in physiology · 2018Review
- Importance of Altered Levels of SERCA, IPBiophysical journal · 2017Article
- Endocannabinoids in cerebrovascular regulation.American journal of physiology. Heart and circulatory physiology · 2016Review
- Brain ischemia in patients with intracranial hemorrhage: pathophysiological reasoning for aggressive diagnostic management.The neuroradiology journal · 2013Review
- Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- MicroRNAs are essential for stretch-induced vascular smooth muscle contractile differentiation via microRNA (miR)-145-dependent expression of L-type calcium channels.The Journal of biological chemistry · 2012Article
- Contribution of flow-dependent vasomotor mechanisms to the autoregulation of cerebral blood flow.Journal of vascular research · 2012Review
- Pressure-dependent contribution of Rho kinase-mediated calcium sensitization in serotonin-evoked vasoconstriction of rat cerebral arteries.The Journal of physiology · 2010Article
- Ca2+ sensitization via phosphorylation of myosin phosphatase targeting subunit at threonine-855 by Rho kinase contributes to the arterial myogenic response.The Journal of physiology · 2009Article
- Src family tyrosine kinases mediate contraction of rat isolated tail arteries in response to a hyposmotic stimulus.Journal of hypertension · 2007Article
- Cholinergic receptor and cyclic stretch-mediated inflammatory gene expression in intact ASM.American journal of respiratory cell and molecular biology · 2006Article
- Intrinsic responses of rat coronary arteries in vitro: influence of testosterone, calcium, and effective transmural pressure.Endocrine · 2002Article
- Effects of mibefradil and nifedipine on arteriolar myogenic responsiveness and intracellular Ca(2+).British journal of pharmacology · 2000Article
- Streptomycin inhibition of myogenic tone, K+-induced force and block of L-type calcium current in rat cerebral arteries.The Journal of physiology · 1998Article
- Regulation of arterial diameter and wall [Ca2+] in cerebral arteries of rat by membrane potential and intravascular pressure.The Journal of physiology · 1998Article
- Evidence both L-type and non-L-type voltage-dependent calcium channels contribute to cerebral artery vasospasm following loss of NO in the rat.Vascular pharmacologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
1. Tissue blood flow and blood pressure are regulated by the spontaneous, myogenic, contraction developed by resistance arteries. However, the cellular mechanisms underlying myogenic contraction are not understood. In this study, the mechanisms of myogenic contraction in cerebral resistance arteries were investigated. 2. The vasoconstriction observed in response to increased pressure in cerebral resistance arteries (myogenic reactivity) was dependent on Ca2+ entry through voltage-dependent Ca2+ channels, since it was abolished by Ca2+ removal and by dihydropyridine antagonists of voltage-dependent Ca2+ channels. 3. Myogenic reactivity persisted in a high-K+ saline, with reduced Ca2+, where membrane potential is presumed to be clamped. Therefore, membrane depolarization alone does not fully account for the increased voltage-dependent Ca2+ channel opening. 4. Voltage-dependent Ca2+ currents in single smooth muscle cells isolated from the resistance artery were substantially increased by applying positive pressure to the patch electrode evoking membrane stretch. 5. Myogenic reactivity remained unaffected by ryanodine and therefore was independent of internal ryanodine-sensitive Ca2+ stores. 6. The myofilament Ca2+ sensitivity was not increased by elevated pressure in alpha-toxin-permeabilized arteries. However, pharmacological activation of protein kinase C or G proteins did increase the myofilament Ca2+ sensitivity. 7. Myogenic contraction over the pressure range 30-70 mmHg could be accounted for by an increase in [Ca2+]i from 100 to 200 nM. 8. It is concluded that modest increases in [Ca2+]i within the range 100-200 nM can account for that myogenic contraction, and that stretch-evoked modulation of Ca2+ currents may contribute to the myogenic response.
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