ArticleThe Journal of physiology1997
Ca2+ release from internal stores: role in generating depolarizing after-potentials in rat supraoptic neurones.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 83 citations in OpenAlex.
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- Endoplasmic Reticulum and Mitochondrial Calcium Handling Dynamically Shape Slow Afterhyperpolarizations in Vasopressin Magnocellular Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Regulation of corticotropin-releasing hormone neuronal network activity by noradrenergic stress signals.The Journal of physiology · 2022Article
- Plasticity in Intrinsic Excitability of Hypothalamic Magnocellular Neurosecretory Neurons in Late-Pregnant and Lactating Rats.International journal of molecular sciences · 2021Article
- Electrophysiological properties of identified oxytocin and vasopressin neurones.Journal of neuroendocrinology · 2019Review
- Oxytocin Neurones: Intrinsic Mechanisms Governing the Regularity of Spiking Activity.Journal of neuroendocrinology · 2016Article
- Rebound discharge in deep cerebellar nuclear neurons in vitro.Cerebellum (London, England) · 2010Review
- Two slow calcium-activated afterhyperpolarization currents control burst firing dynamics in gonadotropin-releasing hormone neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The adaptive brain: Glenn Hatton and the supraoptic nucleus.Journal of neuroendocrinology · 2010Review
- Glutamatergic inputs contribute to phasic activity in vasopressin neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Feedback inhibition of action potential discharge by endogenous adenosine enhancement of the medium afterhyperpolarization.The Journal of physiology · 2009Article
- Somato-dendritic mechanisms underlying the electrophysiological properties of hypothalamic magnocellular neuroendocrine cells: a multicompartmental model study.Journal of computational neuroscience · 2007Article
- Physiologic regulation of a tetrodotoxin-sensitive sodium influx that mediates a slow afterdepolarization potential in gonadotropin-releasing hormone neurons: possible implications for the central regulation of fertility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Phasic spike patterning in rat supraoptic neurones in vivo and in vitro.The Journal of physiology · 2004Article
- Autocrine feedback inhibition of plateau potentials terminates phasic bursts in magnocellular neurosecretory cells of the rat supraoptic nucleus.The Journal of physiology · 2004Article
- Burst initiation and termination in phasic vasopressin cells of the rat supraoptic nucleus: a combined mathematical, electrical, and calcium fluorescence study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Distribution of K+-dependent Na+/Ca2+ exchangers in the rat supraoptic magnocellular neuron is polarized to axon terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Flufenamic acid blocks depolarizing afterpotentials and phasic firing in rat supraoptic neurones.The Journal of physiology · 2002Article
- Synaptic potentials mediated by alpha 7 nicotinic acetylcholine receptors in supraoptic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Ionic basis of the caesium-induced depolarisation in rat supraoptic nucleus neurones.The Journal of physiology · 2001Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. Influences of Ca2+ release from internal stores on the generation of depolarizing after-potentials (DAPs) were investigated in magnocellular neurones of rat supraoptic nucleus (SON) using whole-cell patch recording techniques in brain slices. 2. DAPs were recorded from more than half of the cells encountered, and following evoked single spikes had an amplitude of 3.00 +/- 0.19 mV (mean +/- S.E.M.) and lasted for 1.02 +/- 0.06 s. Their sizes usually increased with the number of preceding spikes, but could be reduced or eliminated when intervals between consecutive current pulses evoking tens of spikes were short. 3. DAPs were eliminated by removal of external Ca2+, and significantly reduced by bath application of nifedipine or omega-conotoxin. 4. Blockade of Ca2+ release from internal stores by perifusion with ryanodine or dantrolene, or direct diffusion of Ruthenium Red into cells suppressed DAP amplitudes by approximately 50% and shortened their durations. 5. Depletion of internal Ca2+ stores by perifusion with thapsigargin or cyclopiazonic acid also reduced DAP amplitudes by approximately 50% and eliminated phasic patterns of firing. 6. Caffeine, an agent known to enhance intracellular Ca2+ release, amplified DAPs and promoted phasic firing. 7. These results suggest that Ca2+ influx via high-voltage-activated Ca2+ channels in SON cells triggers ryanodine receptor-mediated Ca2+ release from internal stores. This process enhances DAPs and promotes phasic firing in SON cells, and would thus contribute to vasopressin release.
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