ArticleThe Biochemical journal1997
PACE4: a subtilisin-like endoprotease with unique properties.
Article in The Biochemical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 59 citations in OpenAlex.
- Antigens in membranous nephropathy: discovery and clinical implications.Nature reviews. Nephrology · 2025Review
- Proprotein Convertase Subtilisin/Kexin 6 in Cardiovascular Biology and Disease.International journal of molecular sciences · 2022Review
- Epigenetic repression of gonadotropin gene expression via a GnRH-mediated DNA delivery system.Gene therapy · 2022Article
- Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.Acta dermato-venereologica · 2020Article
- Extracellular Processing of Lysyl Oxidase-like 2 and Its Effect on Amine Oxidase Activity.Biochemistry · 2018Article
- Proprotein convertase subtilisin/kexin type 6 activates the extracellular signal-regulated kinase 1/2 and Wnt family member 3A pathways and promotesOncology letters · 2018Article
- Comment on: PACE4 (PCSK6): another proprotein convertase linked to iron homeostasis?Haematologica · 2015Article
- Prokaryote-derived protein inhibitors of peptidases: A sketchy occurrence and mostly unknown function.Biochimie · 2010Review
- Deorphanization of novel peptides and their receptors.The AAPS journal · 2010Review
- Proprotein convertase inhibition results in decreased skin cell proliferation, tumorigenesis, and metastasis.Neoplasia (New York, N.Y.) · 2010Article
- 7B2 prevents unfolding and aggregation of prohormone convertase 2.Endocrinology · 2008Article
- Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency.The Journal of clinical investigation · 2003Article
- Mutational analysis of predicted interactions between the catalytic and P domains of prohormone convertase 3 (PC3/PC1).Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Gene expression in epithelial ovarian carcinoma.Oncogene · 2002Article
- Processing of proSAAS in neuroendocrine cell lines.The Biochemical journal · 2002Article
- Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain.The Biochemical journal · 1999Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
PACE4 is one of the neuroendocrine-specific mammalian subtilisin-related endoproteases believed to function in the secretory pathway. The biosynthesis and secretion of PACE4 have been studied using transfected neuroendocrine and fibroblast cell lines. as well as primary pituitary cultures. ProPACE4 (approx. 106 kDa) is cleaved intracellularly before secretion of PACE4 (approx. 97 kDa); the N-terminal propeptide cleavage is accelerated in a truncated form of PACE4 lacking the Cys-rich C-terminal region (PACE4s). Neither PACE4 nor PACE4s is stored in regulated neuroendocrine secretory granules, whereas pro-opiomelanocortin-derived peptides and prohormone convertase I enter the regulated secretory pathway efficiently. The relatively slow cleavage of the proregion of proPACE4 in primary anterior pituitary cells, followed by rapid secretion of PACE4, is similar to the results for proPACE4 in transfected cell lines. The enzyme activity of PACE4 is distinct from furin and prohormone convertases, both in the marked sensitivity of PACE4 to inhibition by leupeptin and the relative insensitivity of PACE4 to inhibition by Ca2+ chelators and dithiothreitol; PACE4 is not inhibited by the alpha1-antitrypsin Portland variant that is very potent at inhibiting furin. The unique biosynthetic and enzymic patterns seen for PACE4 suggest a role for this neuroendocrine-specific subtilisin-like endoprotease outside the pathway for peptide biosynthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.