ArticleJournal of virology1997
Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005301 (Transfusion Safety Study), which is not on this map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Transfusion Safety Study (TSS)
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Variation in Intra-individual Lentiviral Evolution Rates: a Systematic Review of Human, Nonhuman Primate, and Felid Species.Journal of virology · 2019Pooled it
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- Adaptation of advanced clinical virology assays from HIV-1 to SARS-CoV-2.Current opinion in HIV and AIDS · 2021Review
- Rapid evolution of the env gene leader sequence in cats naturally infected with feline immunodeficiency virus.The Journal of general virology · 2015Article
- Homogenous HIV-1 subtype B quasispecies in Brazilian men and women recently infected via heterosexual transmission.Virus genes · 2014Article
- Birds shed RNA-viruses according to the pareto principle.PloS one · 2013Article
- Unravelling transmission trees of infectious diseases by combining genetic and epidemiological data.Proceedings. Biological sciences · 2012Article
- Molecular epidemiology of feline immunodeficiency virus in the domestic cat (Felis catus).Veterinary immunology and immunopathology · 2010Review
- V3 loop sequence space analysis suggests different evolutionary patterns of CCR5- and CXCR4-tropic HIV.PloS one · 2009Article
- Highly diversified multiply drug-resistant HIV-1 quasispecies in PBMCs: a case report.Retrovirology · 2008Article
- Integrating genetic and epidemiological data to determine transmission pathways of foot-and-mouth disease virus.Proceedings. Biological sciences · 2008Article
- Functional diversity of HIV-1 envelope proteins expressed by contemporaneous plasma viruses.Retrovirology · 2008Article
- Molecular epidemiology of the foot-and-mouth disease virus outbreak in the United Kingdom in 2001.Journal of virology · 2006Article
- Selection for human immunodeficiency virus type 1 recombinants in a patient with rapid progression to AIDS.Journal of virology · 2002Article
- Compartmentalization of surface envelope glycoprotein of human immunodeficiency virus type 1 during acute and chronic infection.Journal of virology · 2002Article
- Genetic evolution of structural region of hepatitis C virus in primary infection.World journal of gastroenterology · 2002Article
- Antigenic variation within the CD4 binding site of human immunodeficiency virus type 1 gp120: effects on chemokine receptor utilization.Journal of virology · 2001Article
- Article
- An algorithm for mapping positively selected members of quasispecies-type viruses.BMC bioinformatics · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
To investigate the process of human immunodeficiency virus type 1 (HIV-1) evolution in vivo, a total of 179 HIV-1 V3 sequences derived from cell-free plasma were determined from serial samples in three epidemiologically linked individuals (one infected blood donor and two transfusion recipients) over a maximum period of 8 years. A systematic analysis of pairwise comparisons of intrapatient sequences, both within and between each sample time point, revealed a preponderance and accumulation of nonsynonymous rather than synonymous substitutions in the V3 loop and flanking regions as they diverged over time. This strongly argues for the dominant role that positive selection for amino acid change plays in governing the pattern and process of HIV-1 env V3 evolution in vivo and nullifies hypotheses of purely neutral or mutation-driven evolution or completely chance events. In addition, different rates of evolution of HIV-1 were observed in these three different individuals infected with the same viral strain, suggesting that the degree of positive pressure for HIV-1 amino acid change is host dependent. Finally, the observed similar rate of accumulation in divergence within and between infected individuals suggests that the process of genetic divergence in the HIV epidemic proceeds regardless of host-to-host transmission events, i.e., that transmission does not reset the evolutionary clock.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.