ArticleJournal of virology1997
Distinct domains of M-T2, the myxoma virus tumor necrosis factor (TNF) receptor homolog, mediate extracellular TNF binding and intracellular apoptosis inhibition.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 97 citations in OpenAlex.
- The Role of Myxoma Virus Immune Modulators and Host Range Factors in Pathogenesis and Species Leaping.Viruses · 2025Review
- TNF Decoy Receptors Encoded by Poxviruses.Pathogens (Basel, Switzerland) · 2021Review
- Insights into ligand binding by a viral tumor necrosis factor (TNF) decoy receptor yield a selective soluble human type 2 TNF receptor.The Journal of biological chemistry · 2019Article
- Virus Infection and Death Receptor-Mediated Apoptosis.Viruses · 2017Review
- Review
- The current status and future directions of myxoma virus, a master in immune evasion.Veterinary research · 2011Review
- Identification of host range mutants of myxoma virus with altered oncolytic potential in human glioma cells.Journal of neurovirology · 2007Article
- Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death.Journal of virology · 2006Article
- Modulation of tumor necrosis factor by microbial pathogens.PLoS pathogens · 2006Review
- Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak.Journal of virology · 2004Article
- Article
- Lessons in détente or know thy host: the immunomodulatory gene products of myxoma virus.Journal of biosciences · 2003Review
- Viral mimicry of cytokines, chemokines and their receptors.Nature reviews. Immunology · 2003Review
- To kill or be killed: viral evasion of apoptosis.Nature immunology · 2002Review
- Adenovirus E3-6.7K maintains calcium homeostasis and prevents apoptosis and arachidonic acid release.Journal of virology · 2002Article
- Poxvirus homologues of cellular genes.Virus genes · 2000Review
- Article
- Human cytomegalovirus UL144 open reading frame: sequence hypervariability in low-passage clinical isolates.Journal of virology · 1999Article
- TNF-induced signaling in apoptosis.Journal of clinical immunology · 1999Review
- Serp2, an inhibitor of the interleukin-1beta-converting enzyme, is critical in the pathobiology of myxoma virus.Journal of virology · 1998Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The myxoma virus tumor necrosis factor (TNF) receptor homolog, M-T2, is expressed both as a secreted glycoprotein that inhibits the cytolytic activity of rabbit TNF-alpha and as an endoglycosidase H-sensitive intracellular species that prevents myxoma virus-infected CD4+ T lymphocytes from undergoing apoptosis. To compare the domains of M-T2 mediating extracellular TNF inhibition and intracellular apoptosis inhibition, recombinant myxoma viruses expressing nested C-terminal truncations of M-T2 protein were constructed. One mutant, deltaL113, containing intact copies of only two cysteine-rich domains, was not secreted and was incapable of binding rabbit TNF-alpha yet retained full ability to inhibit virus-induced apoptosis of RL-5 cells. Thus, the minimal domain of intracellular M-T2 protein required to inhibit apoptosis is distinct from that required by the extracellular M-T2 for functional TNF-alpha binding and inhibition. This is the first report of a virus-encoded immunomodular protein with two distinct antiimmune properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.