ArticleJournal of virology1997
The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon.
Article in Journal of virology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- TCR independent suppression of CD8(+) T cell cytokine production mediated by IFNγ in vivo.Virology · 2016Article
- Impaired CD8(+) T cell immunity after allogeneic bone marrow transplantation leads to persistent and severe respiratory viral infection.Transplant immunology · 2015Article
- CD8 T cells use IFN-γ to protect against the lethal effects of a respiratory poxvirus infection.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Reduced inflammation and altered innate response in neonates during paramyxoviral infection.Virology journal · 2011Article
- Regulation of the induction and function of cytotoxic T lymphocytes by natural killer T cell.Journal of biomedicine & biotechnology · 2010Article
- Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells.Journal of virology · 2005Article
- The role of IL-12, IL-23 and IFN-gamma in immunity to viruses.Cytokine & growth factor reviews · 2004Review
- The regulation and maturation of antiviral immune responses.Advances in virus research · 2004Review
- Viral induction of a chronic asthma phenotype and genetic segregation from the acute response.The Journal of clinical investigation · 2002Article
- Inhibition of major histocompatibility complex class II-dependent antigen presentation by neutralization of gamma interferon leads to breakdown of resistance against measles virus-induced encephalitis.Journal of virology · 2001Article
- Nitric oxide and virus infection.Immunology · 2000Review
- Role of the individual interferon systems and specific immunity in mice in controlling systemic dissemination of attenuated pseudorabies virus infection.Journal of virology · 1999Article
- Immune response to mouse mammary tumor virus in mice lacking the alpha/beta interferon or the gamma interferon receptor.Journal of virology · 1998Article
- Clearance of an influenza A virus by CD4+ T cells is inefficient in the absence of B cells.Journal of virology · 1998Article
- Modification of the Sendai virus-specific antibody and CD8+ T-cell responses in mice homozygous for disruption of the interleukin-4 gene.Journal of virology · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Sendai virus is eliminated from the respiratory tract of gamma interferon (IFN-gamma) -/- BALB/c mice with normal kinetics. The level of virus-specific cytotoxic T-lymphocyte (CTL) activity in the cell population recovered by bronchoalveolar lavage is unimpaired, the prevalence of interleukin-4 (IL-4)-producing cells is increased, and the titers of virus-specific immunoglobulins IgG1 and IgG2b are higher in the IFN-gamma -/- mice. The emergence of this T-helper 2 response profile in both lymphoid tissue and the pneumonic lung has no obvious deleterious consequences. Virus clearance is slightly delayed following depletion of the CD4+ subset, with the effect being similar in magnitude for IFN-gamma -/- and +/+ mice. However, the generation of CTL precursors (CTLp) is diminished in the IFN-gamma -/- (but not +/+) mice in the absence of concurrent CD4+ T help. Apparently the clonal expansion of the CTLp population can be promoted either by a cytokine (perhaps IL-2) produced by the IFN-gamma -/- CD4+ T cells or by IFN-gamma made by other cell types in the +/+ mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.