ArticleMolecular and cellular biology1997
Transcription mediated by NFAT is highly inducible in effector CD4+ T helper 2 (Th2) cells but not in Th1 cells.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 116 citations in OpenAlex.
- How does NFAT3 regulate the occurrence of cardiac hypertrophy?International journal of cardiology. Heart & vasculature · 2023Review
- Condyloma acuminata: An evaluation of the immune response at cellular and molecular levels.PloS one · 2023Article
- Cross‑validation of genes potentially associated with neoadjuvant chemotherapy and platinum‑based chemoresistance in epithelial ovarian carcinoma.Oncology reports · 2020Article
- Genetic deletion of soluble epoxide hydrolase delays the progression of Alzheimer's disease.Journal of neuroinflammation · 2019Article
- Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease.Journal of neuroinflammation · 2016Article
- Lead induces COX-2 expression in glial cells in a NFAT-dependent, AP-1/NFκB-independent manner.Toxicology · 2014Article
- The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival.The Journal of biological chemistry · 2014Article
- Article
- Transcriptional control of rapid recall by memory CD4 T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells.The Journal of experimental medicine · 2009Article
- Accumulation of NFAT mediates IL-2 expression in memory, but not naïve, CD4+ T cells.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- RSK2 mediates muscle cell differentiation through regulation of NFAT3.The Journal of biological chemistry · 2007Article
- NFAT3 is required for EGF-induced COX-2 transcription, but neither iNOS transcription nor cell transformation in Cl 41 cells.Molecular and cellular biochemistry · 2006Article
- Carcinogenic effect of nickel compounds.Molecular and cellular biochemistry · 2005Review
- Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression.The EMBO journal · 2005Article
- Expression of human pim family genes is selectively up-regulated by cytokines promoting T helper type 1, but not T helper type 2, cell differentiation.Immunology · 2005Article
- Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2004Article
- Development of colitis in signal transducers and activators of transcription 6-deficient T-cell receptor alpha-deficient mice: a potential role of signal transducers and activators of transcription 6-independent interleukin-4 signaling for the generation of Th2-biased pathological CD4+ betabetaT cells.The American journal of pathology · 2003Article
- Role of bioavailable iron in coal dust-induced activation of activator protein-1 and nuclear factor of activated T cells: difference between Pennsylvania and Utah coal dusts.American journal of respiratory cell and molecular biology · 2002Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Transcriptional factors of the NFAT family play an important role in regulating the expression of several cytokine genes during the immune response, such as the genes for interleukin 2 (IL-2) and IL-4, among others. Upon antigen stimulation, precursor CD4+ T helper (pTh) cells proliferate and differentiate into two populations of effector cells (eTh1 and eTh2), each one expressing a specific pattern of cytokines that distinguishes them from their precursors. eTh2 cells are the major source of IL-4, while gamma interferon is produced by eTh1 cells. Here we have used reporter transgenic mice to show that DNA binding and transcriptional activities of NFAT are transiently induced during the differentiation of pTh cells into either eTh1 or eTh2 cells to mediate the expression of IL-2 as a common growth factor in both pathways. However, although NFAT DNA binding is similarly induced in both eTh1 and eTh2 cells upon antigen stimulation, only the NFAT complexes present in eTh2 cells are able to mediate high-level transcription, and relatively little NFAT transcriptional activity was induced in eTh1 cells. In contrast to activated pTh cells, neither eTh1 nor eTh2 cells produced significant IL-2 upon stimulation, but the high levels of NFAT transcriptional activities directly correlate with the IL-4 production induced in response to antigen stimulation in eTh2 cells. These data suggest that activated NFAT is involved in the effector function of eTh2 cells and that the failure of eTh1 cells to produce IL-4 in response to an antigen is due, at least partially, to a failure to induce high-level transcription of the IL-4 gene by NFAT. Regulation of NFAT could be therefore a critical element in the polarization to eTh1 or eTh2.
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