ArticleMolecular and cellular biology1997
The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 104 citations in OpenAlex.
- Article
- Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core.ACS chemical biology · 2013Article
- Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation.The Journal of biological chemistry · 2012Article
- Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway.Blood cells, molecules & diseases · 2011Article
- CTCF-dependent enhancer-blocking by alternative chromatin loop formation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Interrogating domain-domain interactions with parsimony based approaches.BMC bioinformatics · 2008Article
- Beta-globin intergenic transcription and histone acetylation dependent on an enhancer.Molecular and cellular biology · 2007Article
- Sumoylation of p45/NF-E2: nuclear positioning and transcriptional activation of the mammalian beta-like globin gene locus.Molecular and cellular biology · 2005Article
- An insulator blocks spreading of histone acetylation and interferes with RNA polymerase II transfer between an enhancer and gene.Nucleic acids research · 2004Article
- The thyroid hormone receptor antagonizes CREB-mediated transcription.The EMBO journal · 2003Article
- A major role for the TATA box in recruitment of chromatin modifying complexes to a globin gene promoter.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation.Genes & development · 2003Article
- Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1.Molecular and cellular biology · 2003Article
- Cooperative activities of hematopoietic regulators recruit RNA polymerase II to a tissue-specific chromatin domain.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1.Molecular and cellular biology · 2002Article
- Requirements for utilization of CREB binding protein by hypersensitive site two of the beta-globin locus control region.Nucleic acids research · 2002Article
- Nuclear relocation of a transactivator subunit precedes target gene activation.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Activation of beta-major globin gene transcription is associated with recruitment of NF-E2 to the beta-globin LCR and gene promoter.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Acetylation of a specific promoter nucleosome accompanies activation of the epsilon-globin gene by beta-globin locus control region HS2.Molecular and cellular biology · 2001Article
- Stimulation of CREB binding protein nucleosomal histone acetyltransferase activity by a class of transcriptional activators.Molecular and cellular biology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Thyroid hormone (T3) and retinoic acid (RA) play important roles in erythropoiesis. We found that the hematopoietic cell-specific bZip protein p45/NF-E2 interacts with T3 receptor (TR) and RA receptor (RAR) but not retinoid X receptor. The interaction is between the DNA-binding domain of the nuclear receptor and the leucine zipper region of p45/NF-E2 but is markedly enhanced by cognate ligand. Remarkably, ligand-dependent transactivation by TR and RAR is markedly potentiated by p45/NF-E2. This effect of p45/NF-E2 is prevented by maf-like protein p18, which functions positively as a heterodimer with p45/NF-E2 on DNA. Potentiation of hormone action by p45/NF-E2 requires its activation domain, which interacts strongly with the multifaceted coactivator cyclic AMP response element protein-binding protein (CBP). The region of CBP which interacts with p45/NF-E2 is the same interaction domain that mediates inhibition of hormone-stimulated transcription by AP1 transcription factors. Overexpression of the bZip interaction domain of CBP specifically abolishes the positive cross talk between TR and p45/NF-E2. Thus, positive cross talk between p45/NF-E2 and nuclear hormone receptors requires direct protein-protein interactions between these factors and with CBP, whose integration of positive signals from two transactivation domains provides a novel mechanism for potentiation of hormone action in hematopoietic cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.