ArticleMolecular and cellular biology1997
Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 96 citations in OpenAlex.
- Trial
- Characterisation of a nucleo-adhesome.Nature communications · 2022Article
- The Leptin induced Hic-5 expression and actin puncta formation by the FAK/Src-dependent pathway in MCF10A mammary epithelial cellsBiomedica : revista del Instituto Nacional de Salud · 2019Article
- Aging up-regulates ARA55 in stromal cells, inducing androgen-mediated prostate cancer cell proliferation and migration.Journal of molecular histology · 2016Article
- Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells.Investigative ophthalmology & visual science · 2015Article
- Interactions between E6, FAK, and GIT1 at paxillin LD4 are necessary for transformation by bovine papillomavirus 1 E6.Journal of virology · 2014Article
- Negative regulation of NADPH oxidase 4 by hydrogen peroxide-inducible clone 5 (Hic-5) protein.The Journal of biological chemistry · 2014Article
- Hic-5 controls BMP4 responses in prostate cancer cells through interacting with Smads 1, 5 and 8.Oncogene · 2012Article
- Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition.The Journal of cell biology · 2012Article
- HIC-5: A Mobile Molecular Scaffold Regulating the Anchorage Dependence of Cell Growth.International journal of cell biology · 2012Article
- Article
- Cellular senescence as a target in cancer control.Journal of aging research · 2010Article
- Bypassing cellular senescence by genetic screening tools.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2010Review
- Paxillin and hydrogen peroxide-inducible clone 5 expression and distribution in control and Alzheimer disease hippocampi.Journal of neuropathology and experimental neurology · 2010Article
- Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55.Oncogene · 2008Article
- Critical pathways in cellular senescence and immortalization revealed by gene expression profiling.Oncogene · 2008Review
- Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop.The Journal of investigative dermatology · 2008Article
- Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Hic-5 communicates between focal adhesions and the nucleus through oxidant-sensitive nuclear export signal.Molecular biology of the cell · 2003Article
- The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hic-5 gene encodes a novel protein with Zn finger-like (LIM) motifs, the expression of which increases during cellular senescence. The ectopic expression of hic-5 in nontumorigenic immortalized human fibroblasts, whose expression levels of hic-5 were significantly reduced in comparison with those of mortal cells, decreased colony-forming efficiency. Stable clones expressing high levels of hic-5 mRNA showed higher levels of mRNAs for several extracellular matrix-related proteins, along with the alteration of an alternative splicing as seen in senescent cells and decreased c-fos inducibility. Furthermore, these clones acquired a senescence-like phenotype, such as growth retardation; senescence-like morphology; and increased expression of Cip1/WAF1/sdi1 after 20 to 40 population doublings. On the other hand, antisense RNA expression of hic-5 in human normal diploid fibroblasts delayed the senescence process. HIC-5 was localized in nuclei and had affinity for DNA. Based on these observations, we speculated that HIC-5 affected the expression of senescence-related genes through interacting with DNA and thereby induced the senescence-like phenotypes. To our knowledge, hic-5 is the first single gene that could induce senescence-like phenotypes in a certain type of immortalized human cell and mediate the normal process of senescence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.