ArticleMolecular and cellular biology1997
The five cleavage-stage (CS) histones of the sea urchin are encoded by a maternally expressed family of replacement histone genes: functional equivalence of the CS H1 and frog H1M (B4) proteins.
Article in Molecular and cellular biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 50 citations in OpenAlex.
- A rapidly evolving single copy histone H1 variant is associated with male fertility in a parasitoid wasp.Frontiers in cell and developmental biology · 2023Article
- Novel Classes and Evolutionary Turnover of Histone H2B Variants in the Mammalian Germline.Molecular biology and evolution · 2022Article
- The tumour suppressor brain tumour (Brat) regulates linker histone dBigH1 expression in theOpen biology · 2021Article
- Alternative linker histone permits fast paced nuclear divisions in early Drosophila embryo.Nucleic acids research · 2020Article
- Germline-specific H1 variants: the "sexy" linker histones.Chromosoma · 2016Review
- Quantitative developmental transcriptomes of the sea urchin Strongylocentrotus purpuratus.Developmental biology · 2014Article
- Epigenetic reprogramming and development: a unique heterochromatin organization in the preimplantation mouse embryo.Briefings in functional genomics · 2010Article
- Oocyte-type linker histone B4 is required for transdifferentiation of somatic cells in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail.Nature reviews. Genetics · 2008Review
- Concerted and birth-and-death evolution of multigene families.Annual review of genetics · 2005Review
- Involvement of retinoblastoma protein and HBP1 in histone H1(0) gene expression.Molecular and cellular biology · 2000Article
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6 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The cleavage-stage (CS) histones of the sea urchin are known to be maternally expressed in the egg, have been implicated in chromatin remodeling of the male pronucleus following fertilization, and are the only histone variants present in embryonic chromatin up to the four-cell stage. With the help of partial peptide sequence information, we have isolated and identified CS H1, H2A, H2B, H3, and H4 cDNAs from egg poly(A)+ mRNA of the sea urchin Psammechinus miliaris. All five CS proteins correspond to replacement histone variants which are encoded by replication-independent genes containing introns, poly(A) addition signals, and long nontranslated sequences. Transcripts of the CS histone genes could be detected only during oogenesis and in development up to the early blastula stage. The CS proteins, with the exception of H4, are unique histones which are distantly related in sequence to the early, late, and sperm histone subtypes of the sea urchin. In contrast, the CS H1 protein displays highest sequence homology with the H1M (B4) histone of Xenopus laevis. Both H1 proteins are replacement histone variants with very similar developmental expression profiles in their respective species, thus indicating that the frog H1M (B4) gene is a vertebrate homolog of the CS H1 gene. These data furthermore suggest that the CS histones are of ancient evolutionary origin and may perform similar conserved functions during oogenesis and early development in different species.
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