ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1997
Facilitation of N-type calcium current is dependent on the frequency of action potential-like depolarizations in dissociated cholinergic basal forebrain neurons of the guinea pig.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 65 citations in OpenAlex.
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- Noradrenergic refinement of glutamatergic neuronal circuits in the lateral superior olivary nucleus before hearing onset.Journal of neurophysiology · 2015Article
- Regulation of Ca(V)2 calcium channels by G protein coupled receptors.Biochimica et biophysica acta · 2013Review
- The ß subunit of voltage-gated Ca2+ channels.Physiological reviews · 2010Review
- Origin of the voltage dependence of G-protein regulation of P/Q-type Ca2+ channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Importance of voltage-dependent inactivation in N-type calcium channel regulation by G-proteins.Pflugers Archiv : European journal of physiology · 2007Article
- G-proteins modulate cumulative inactivation of N-type (Cav2.2) calcium channels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Neurotransmitter modulation of neuronal calcium channels.Journal of bioenergetics and biomembranes · 2003Review
- Differential facilitation of N- and P/Q-type calcium channels during trains of action potential-like waveforms.The Journal of physiology · 2002Article
- Reluctant gating of single N-type calcium channels during neurotransmitter-induced inhibition in bullfrog sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Modulation of N-type calcium channel activity by G-proteins and protein kinase C.The Journal of general physiology · 2000Article
- Relief of G-protein inhibition of calcium channels and short-term synaptic facilitation in cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Kinetic study of N-type calcium current modulation by delta-opioid receptor activation in the mammalian cell line NG108-15.Biophysical journal · 1999Article
- The role of N-, Q- and R-type Ca2+ channels in feedback inhibition of ACh release from rat basal forebrain neurones.The Journal of physiology · 1999Article
- Dynamic regulation of calcium influx by G-proteins, action potential waveform, and neuronal firing frequency.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Mechanisms of modulation of voltage-dependent calcium channels by G proteins.The Journal of physiology · 1998Review
- Distinct contributions of high- and low-voltage-activated calcium currents to afterhyperpolarizations in cholinergic nucleus basalis neurons of the guinea pig.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voltage-dependent inhibition of high voltage-activated (HVA) calcium currents by G-proteins can be transiently relieved (facilitated) by strong depolarizing prepulses. However, with respect to the physiological significance of facilitation, it remains to be established if it can be induced by action potentials (AP) in central neurons. With the use of whole-cell recordings of dissociated cholinergic basal forebrain neurons of the guinea pig, it is shown that the GTPgammaS-inhibited HVA currents that occur through N-ethylmaleimide (NEM)-sensitive Gi-Go subtypes of G-proteins can be facilitated. Furthermore, although different types of HVA channels are present in these neurons, facilitation occurred mostly through disinhibition of the N-type current. On the basis of data indicating that the recovery from facilitation was relatively slow, we tested if more physiological stimuli that crudely mimicked APs (2 msec long depolarizations to 40 mV from a holding of -50 mV) potentially could induce facilitation of HVA currents inhibited by GTPgammaS and cholinergic agonists. Indeed, evidence is provided that the extent of facilitation is dependent on both the number and frequency of AP-like depolarizations. These results suggest that firing rates and patterns of discharge of neurons could influence their responsiveness to transmitters acting on N-type HVA calcium channels.
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9030622PMC6573384W1673114315What OpenQuestion holds
Registered trials
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