ArticleActa neurochirurgica1996
Outcome of 31 intracranial haemangiopericytomas: poor predictive value of cell proliferation indices.
Article in Acta neurochirurgica, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Postoperative stereotactic radiosurgery for intracranial solitary fibrous tumors: systematic review and pooled quantitative analysis.Journal of neuro-oncology · 2023Pooled it
- A review of solitary fibrous tumor/hemangiopericytoma tumor and a comparison of risk factors for recurrence, metastases, and death among patients with spinal and intracranial tumors.Neurosurgical review · 2021Pooled it
- Solitary fibrous tumor of the central nervous system invading and penetrating the skull: A case report.Oncology letters · 2023Article
- Multidisciplinary Treatment of Liver Metastases from Intracranial SFTs/HPCs: A Report of Three Consecutive Cases.Current oncology (Toronto, Ont.) · 2022Article
- The Role of Postoperative Radiotherapy in Intracranial Solitary Fibrous Tumor/Hemangiopericytoma: A Multi-institutional Retrospective Study (KROG 18-11).Cancer research and treatment · 2022Article
- Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system.Journal of neuro-oncology · 2017Article
- The impact of postoperative radiation therapy on patterns of failure and survival improvement in patients with intracranial hemangiopericytoma.Journal of neuro-oncology · 2016Article
- Intracranial Hemangiopericytomas : A Retrospective Study of 15 Patients with a Special Review of Recurrence.Journal of Korean Neurosurgical Society · 2015Article
- Intracranial meningeal hemangiopericytoma: Recurrences at the initial and distant intracranial sites and extraneural metastases to multiple organs.Molecular and clinical oncology · 2015Article
- Clinical characteristics and prognostic analysis of recurrent hemangiopericytoma in the central nervous system: a review of 46 cases.Journal of neuro-oncology · 2013Article
- Clinical analysis of intracranial hemangiopericytoma.Journal of Korean Neurosurgical Society · 2013Article
- A clinicopathological study of diagnostically challenging meningioma mimics.Journal of neuro-oncology · 2012Article
- Hemangiopericytoma: collision with meningioma and recurrence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2010Article
- Meningeal hemangiopericytomas and hemangiopericytoma/solitary fibrous tumors of extracranial soft tissues: a comparison.Virchows Archiv : an international journal of pathology · 2010Article
- Malignant solitary fibrous tumor of the meninges.Virchows Archiv : an international journal of pathology · 2004Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell proliferation indices of 31 primary intracranial haemangiopericytomas (HPC) and their recurrences and metastases were correlated with the long-term recurrence, metastasis and survival rates. Paraffin-embedded specimens were used for K-67, PCNA and p53 immunostainings and for estimation of S-phase fraction (S-PF) in flow cytometry. The median Ki-67 and PCNA indices and S-PFs were 10.4, 3.2, and 4.0 for primary HPCs and 14.1, 14.1, and 5.5 for recurrences, respectively. High indices were associated with higher recurrence, metastasis and death rates, but not at the p < or = 0.5 level. Consequently, these indices do not seem useful in planning of treatment and follow-up of meningeal HPCs. Meningeal HPCs, in contrast to meningiomas, recur almost always despite seemingly complete removal and often metastasize elsewhere in the body. This difference between two sharply demarcated tumours must reflect particularly adhesive and infiltrative properties of HPC cells and not just higher proliferation potential.
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Registered trials
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