ArticleJournal of cancer research and clinical oncology1997
Nerve growth factor stimulates in vitro invasive capacity of DU145 human prostatic cancer cells.
Article in Journal of cancer research and clinical oncology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor.Investigational new drugs · 2005Trial
- Review
- Mini-review: Trophic interactions between cancer cells and primary afferent neurons.Neuroscience letters · 2021Review
- Hallmarks of cancer-the new testament.Open biology · 2021Review
- Nerve Growth Factor Induces Proliferation and Aggressiveness In Prostate Cancer Cells.Cancers · 2019Article
- TRAF4-mediated ubiquitination of NGF receptor TrkA regulates prostate cancer metastasis.The Journal of clinical investigation · 2018Article
- Mechanisms of cancer dissemination along nerves.Nature reviews. Cancer · 2016Review
- Schwann Cells Increase Prostate and Pancreatic Tumor Cell Invasion Using Laminin Binding A6 Integrin.Journal of cellular biochemistry · 2016Article
- Review
- Clinical significance of nerve growth factor and tropomyosin-receptor-kinase signaling pathway in intrahepatic cholangiocarcinoma.World journal of gastroenterology · 2014Article
- Therapeutic potential of perineural invasion, hypoxia and desmoplasia in pancreatic cancer.Current pharmaceutical design · 2012Review
- Targeting the cancer-stroma interaction: a potential approach for pancreatic cancer treatment.Current pharmaceutical design · 2012Review
- Nerve growth factor in cancer cell death and survival.Cancers · 2011Article
- Natural antibodies against nerve growth factor inhibit in vitro prostate cancer cell metastasis.Cancer immunology, immunotherapy : CII · 2011Article
- Mechanism of cancer pain.Molecular interventions · 2010Review
- Nerve growth factor enhances voltage-gated Na+ channel activity and Transwell migration in Mat-LyLu rat prostate cancer cell line.Journal of cellular physiology · 2007Article
- Studies on the differentiation pathway and growth characteristics of epithelial culture cells of the human prostate.Prostate cancer and prostatic diseases · 2004Article
- Role of neurotrophins and neurotrophins receptors in the in vitro invasion and heparanase production of human prostate cancer cells.Clinical & experimental metastasis · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of nerve growth factor (NGF) production in different human prostatic tumor cell lines (DU145, PC-3, LNCaP-FGC) was investigated using a specific enzyme-linked immunosorbent assay (ELISA) and compared to that of different human and rat prostatic tissue samples. In addition, the biological effects of NGF beta addition to the human prostatic cancer cell cultures were investigated. The ELISA technique showed the DU145 cell line to secrete measurable levels of NGF in the culture medium. When neurite-outgrowth determination in a pheochromocytoma cell line was used as a bioassay, the NGF synthesized by DU145 cells was confirmed to exhibit functional biological activity. No effect of exogenously added NGF could be established on tumor cell proliferation, on the basis of either colorimetric tetrazolium-based staining assay or bromodeoxyuridine incorporation. Also the expression of prostate specific acid phosphatase was not influenced by NGF addition. However, the in vitro invasive capacity (Matrigel) of DU145 cells was significantly increased by inclusion of 50 ng or 100 ng NGF beta/ml culture medium. In view of the clinically well-known perineural invasion of prostate cancer cells, the possible involvement of NGF as a (paracrine) factor in prostatic cancer metastatic behavior should be investigated further.
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