ArticleThe EMBO journal1997
Over-expression of GATA-6 in Xenopus embryos blocks differentiation of heart precursors.
Article in The EMBO journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 112 citations in OpenAlex.
- Genetics of atrial fibrillation-an update of recent findings.Molecular biology reports · 2022Review
- Towards Understanding the Gene-Specific Roles of GATA Factors in Heart Development: Does GATA4 Lead the Way?International journal of molecular sciences · 2022Review
- The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis.Developmental biology · 2019Article
- STAT3-Inducible Mouse ESCs: A Model to Study the Role of STAT3 in ESC Maintenance and Lineage Differentiation.Stem cells international · 2018Article
- miR-10a regulates proliferation of human cardiomyocyte progenitor cells by targeting GATA6.PloS one · 2014Article
- Molecular and functional analyses of the fast skeletal myosin light chain2 gene of the Korean oily bitterling, Acheilognathus koreensis.International journal of molecular sciences · 2013Article
- sfrp1 promotes cardiomyocyte differentiation in Xenopus via negative-feedback regulation of Wnt signalling.Development (Cambridge, England) · 2013Article
- Comparative Analysis of Nkx2-5/GATA4/TBX5 Expression in Chicken, Quail and Chicken-quail Hybrids during the Early Stage of Cardiac Development in Embryos.Asian-Australasian journal of animal sciences · 2013Article
- Heavy and light roles: myosin in the morphogenesis of the heart.Cellular and molecular life sciences : CMLS · 2013Review
- A potential relationship among beta-defensins haplotype, SOX7 duplication and cardiac defects.PloS one · 2013Article
- Xenopus Nanos1 is required to prevent endoderm gene expression and apoptosis in primordial germ cells.Development (Cambridge, England) · 2012Article
- Identification of thalidomide-specific transcriptomics and proteomics signatures during differentiation of human embryonic stem cells.PloS one · 2012Article
- Role of human endogenous retroviral long terminal repeats (LTRs) in maintaining the integrity of the human germ line.Viruses · 2011Article
- Identification of GATA6 sequence variants in patients with congenital heart defects.Pediatric research · 2010Article
- miR-145 directs intestinal maturation in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Wnt6 signaling regulates heart muscle development during organogenesis.Developmental biology · 2008Article
- Activation of peroxisome proliferator-activated receptor gamma suppresses mast cell maturation involved in allergic diseases.Allergy · 2008Article
- SHP-2 is required for the maintenance of cardiac progenitors.Development (Cambridge, England) · 2007Article
- GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells.BMC molecular biology · 2007Article
- Cardiovascular genomics: a current overview of in vivo and in vitro studies.Stem cell reviews · 2006Review
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Xenopus GATA-6 transcripts are first detected at the beginning of gastrulation in the mesoderm, and subsequent domains of expression include the field of cells shown to have heart-forming potential. In this region, GATA-6 expression continues only in those cells that go on to form the heart; however, a decrease occurs prior to terminal differentiation. Artificial elevation of GATA-6, but not GATA-1, prevents expression of both cardiac actin and heart-specific myosin light chain. This effect is heart-specific because cardiac actin expression is unaffected in somites. Expression of the earlier marker XNkx-2.5 was unaffected and morphological development of the heart was initiated independently of the establishment of the contractile machinery. We conclude that a reduction in the level of GATA-6 is important for the progression of the cardiomyogenic differentiation programme and that GATA-6 may act to maintain heart cells in the precursor state. At later stages, when the elevated GATA-6 levels had decayed, differentiation ensued but the number of cells contributing to the myocardium had increased, suggesting either that the blocked cells had proliferated or that additional cells had been recruited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.