ReviewDrugs1997
Physiology of chemotherapy-induced emesis and antiemetic therapy. Predictive models for evaluation of new compounds.
Review in Drugs, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 82 citations in OpenAlex.
- The effects of intravenous fosaprepitant and ondansetron for the prevention of postoperative nausea and vomiting in neurosurgery patients: a prospective, randomized, double-blinded study.BioMed research international · 2014Trial
- Gabapentsal ameliorate cisplatin-induced vomiting in pigeons: neurochemical evidences and the involvement of serotonin and dopamine modulation.Scientific reports · 2026Article
- Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems.International journal of molecular sciences · 2021Review
- Suppression of Cisplatin-Induced Vomiting byFrontiers in pharmacology · 2018Article
- Protein calorie malnutrition, nutritional intervention and personalized cancer care.Oncotarget · 2017Review
- Anti-emetic mechanisms of Zingiber officinale against cisplatin induced emesis in the pigeon; behavioral and neurochemical correlates.BMC complementary and alternative medicine · 2015Article
- Identification of a novel marker associated with risk for delayed chemotherapy-induced vomiting.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2012Article
- Receptor-selective agonists induce emesis and Fos expression in the brain and enteric nervous system of the least shrew (Cryptotis parva).Pharmacology, biochemistry, and behavior · 2009Article
- Ablation of least shrew central neurokinin NK1 receptors reduces GR73632-induced vomiting.Behavioral neuroscience · 2009Article
- The antiemetic interaction of Delta9-tetrahydrocannabinol when combined with tropisetron or dexamethasone in the least shrew.Pharmacology, biochemistry, and behavior · 2009Article
- Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists.Brain research · 2008Article
- Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids against radiation-induced emesis in the least shrew.European journal of pharmacology · 2007Article
- Benefits and risks of newer treatments for chemotherapy-induced and postoperative nausea and vomiting.Drug safety · 2003Review
- Ondansetron: a review of its use as an antiemetic in children.Paediatric drugs · 2001Review
- Review
- Comparative receptor mapping of serotoninergic 5-HT3 and 5-HT4 binding sites.Journal of computer-aided molecular design · 1997Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The physiology of emesis has been studied for several hundred years, focusing on the different centres involved and the mechanics of expulsion. The vomiting centre receives inputs from various emetic detectors such as the gut, the vestibular labyrinths and the chemoreceptor trigger zone. Emesis is a common disabling effect in motion sickness, postoperative conditions and in radio- and chemotherapy. Our current understanding of the mechanisms has been provided mainly by the recent introduction of serotonin 5-HT3 receptor antagonists into therapeutic use. Nevertheless, despite the considerable advances made in the understanding of the different pathways involved in emesis, there are number of areas that still require experimental investigation. Different animal and human models are available to study the physiology of emesis and to evaluate the antiemetic activity of new compounds, but they need to be predictors of clinical situations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.