ArticleGut1996
Prevalence of Helicobacter pylori infection and related gastroduodenal lesions in spouses of Helicobacter pylori positive patients with duodenal ulcer.
Article in Gut, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 66 citations in OpenAlex.
- Concurrence of Helicobacter pylori Infection and Its Associated Factors in Korean Couples.Korean journal of family medicine · 2022Article
- Helicobacter pylori, transmission routes and recurrence of infection: state of the art.Acta bio-medica : Atenei Parmensis · 2018Review
- Prevalence ofUnited European gastroenterology journal · 2018Article
- CYTOTOXIC, α-CHYMOTRYPSIN AND UREASE INHIBITION ACTIVITIES OF THE PLANTAfrican journal of traditional, complementary, and alternative medicines : AJTCAM · 2016Article
- Inhibition of Helicobacter pylori and associated urease by oregano and cranberry phytochemical synergies.Applied and environmental microbiology · 2005Article
- Helicobacter pylori infection transmitted sexually via oral-genital contact: a hypothetical model.Sexually transmitted infections · 2000Review
- Rare incidence of interspousal transmission of Helicobacter pylori in asymptomatic individuals in Japan.Journal of clinical microbiology · 1999Article
- Transmission of Helicobacter pylori.Postgraduate medical journal · 1999Review
- Eradication of Helicobacter pylori infection in the management of patients with dyspepsia and non-ulcer dyspepsia.The Yale journal of biology and medicineReview
- Helicobacter pylori infection in family members of patients with gastroduodenal symptoms. A cross-sectional analytical study.Sao Paulo medical journal = Revista paulista de medicinaArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, very few studies have evaluated the risk of infection among spouses of Helicobacter pylori positive patients and their results are conflicting.
aimTo assess the seroprevalence of H pylori infection in spouse of H pylori positive patients with duodenal ulcer as compared with age and sex matched volunteer blood donors, as well as the frequency of endoscopic gastroduodenal lesions in these spouses, according to the presence or absence of gastrointestinal complaints.
methodsSome 124 spouses (48% males) of patients with duodenal ulcer consecutively seen over a 10 month period were studied. They were all screened for serum IgG anti-H pylori antibodies and asked to complete a questionnaire with particular reference to the presence of chronic or recurrent dyspepsia. Upper gastrointestinal tract endoscopy with antral and corpus biopsy specimens taken for histological examination and urease rapid test was offered to all seropositive spouses. Volunteer blood donors (248), living in Milan and matched for age, sex, north-south origins, and socioeconomic status to the cases, were used as controls.
resultsSpouses of patients with duodenal ulcer had a significantly higher seroprevalence of H pylori infection than controls (71% v 58%, p < 0.05); 30 of 88 (34%) H pylori positive spouses complained of dyspeptic symptoms compared with only four of 34 (12%) seronegative spouses (p < 0.02). At endoscopy, H pylori infection was confirmed in 48 of 49 (98%) seropositive spouses. The endoscopic findings in those spouses showed active duodenal ulcer in eight (17%), duodenal scar and cap deformity in two (4%), active gastric ulcer in two (4%), erosive duodenitis in three (6%), antral erosions in two (4%), antral erosions plus duodenitis in one, and peptic oesophagitis in another patient. The prevalence of major endoscopic lesions was significantly higher in symptomatic spouses than in those who had never been symptomatic.
conclusionsThese findings show that being the spouse of an H pylori positive patient with duodenal ulcer may increase the risk of H pylori colonisation and perhaps of peptic ulcer disease, and raises questions as to whether serological screening of cohabiting partners of H pylori positive patients with duodenal ulcer may be indicated.
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