ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology1996
Combined immunocytogenetic and molecular cytogenetic analysis of meiosis I human spermatocytes.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 141 citations in OpenAlex.
- Correlations between Synaptic Initiation and Meiotic Recombination: A Study of Humans and Mice.American journal of human genetics · 2016Article
- Analysis of telomere length in couples experiencing idiopathic recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2013Article
- Homologous pairing preceding SPO11-mediated double-strand breaks in mice.Developmental cell · 2013Article
- Chromosome painting reveals asynaptic full alignment of homologs and HIM-8-dependent remodeling of X chromosome territories during Caenorhabditis elegans meiosis.PLoS genetics · 2011Article
- Telomere DNA deficiency is associated with development of human embryonic aneuploidy.PLoS genetics · 2011Article
- On the origin of crossover interference: A chromosome oscillatory movement (COM) model.Molecular cytogenetics · 2011Article
- Small ubiquitin-related modifier (SUMO)-1, SUMO-2/3 and SUMOylation are involved with centromeric heterochromatin of chromosomes 9 and 1 and proteins of the synaptonemal complex during meiosis in men.Human reproduction (Oxford, England) · 2008Article
- In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Article
- Meiotic synapsis proceeds from a limited number of subtelomeric sites in the human male.American journal of human genetics · 2005Article
- Irregular telomeres impair meiotic synapsis and recombination in mice.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Organization of repetitive DNA sequences at pachytene chromosomes of gilthead seabream Sparus aurata (Pisces, Perciformes).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2000Article
- Demystified ... FISH.Molecular pathology : MP · 1998Review
- Distribution of the Rad51 recombinase in human and mouse spermatocytes.The EMBO journal · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have used a combination of immunocytogenetic and molecular cytogenetic technology on human spermatocytes to investigate (1) meiosis I chromosome pairing, and (2) organization of synaptonemal complex (SC)-associated chromatin with respect to whole chromosome paints, unique DNA sequences and repetitive DNA of heterochromatic blocks, centromeres and telomeres. It is evident that synapsis normally starts at the termini of homologues. In general, synapsis proceeds synchronously from termini towards the centre of bivalents without any indication of interstitial initiation. Some aberrant meiosis I spermatocytes showed asynchronous pairing, demonstrating not only large differences in the degree of SC formation between bivalents, but also chromosome alignment without synapsis as well as clear interstitial synaptic initiation. It may be the case that alignment normally takes place along the entire length of homologues before synapsis occurs and that the potential for synaptic initiation exists along the length of chromosomes. Telomeric sequences were seen tightly associated with the SCs, as might be expected considering their kinetic properties in relation to the nuclear membrane. Other repetitive DNA, i.e. centromeric alpha-satellites and classical satellites of the heterochromatic blocks 1qh and 9qh, were all found to form loops that are associated with SCs only at their bases. A unique DNA cosmid probe (21q22.3) was found to produce a hybridization pattern consisting of spots located outside SC. The fluorescence in situ hybridization (FISH) signals of these spread DNA sequences have a granular appearance, probably reflecting the pattern of coiling and chromatin condensation of the target DNAs.
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