ArticleThe Journal of cell biology1997
Inhibition of a mitotic motor compromises the formation of dendrite-like processes from neuroblastoma cells.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 58 citations in OpenAlex.
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- Mini-review: Microtubule sliding in neurons.Neuroscience letters · 2021Review
- Microtubule Dysfunction: A Common Feature of Neurodegenerative Diseases.International journal of molecular sciences · 2020Review
- Patronin-mediated minus end growth is required for dendritic microtubule polarity.The Journal of cell biology · 2019Article
- Development of multifunctional nanoparticles towards applications in non-invasive magnetic resonance imaging and axonal tracing.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2017Article
- Stability properties of neuronal microtubules.Cytoskeleton (Hoboken, N.J.) · 2016Review
- Microtubules in health and degenerative disease of the nervous system.Brain research bulletin · 2016Review
- A genomic toolkit to investigate kinesin and myosin motor function in cells.Nature cell biology · 2013Article
- Mitotic motors coregulate microtubule patterns in axons and dendrites.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Identification of proteins that interact with podocin using the yeast 2-hybrid system.Yonsei medical journal · 2009Article
- Dynein-dependent motility of microtubules and nucleation sites supports polarization of the tubulin array in the fungus Ustilago maydis.Molecular biology of the cell · 2006Article
- A novel forward genetic screen for identifying mutations affecting larval neuronal dendrite development in Drosophila melanogaster.Genetics · 2006Article
- The origin recognition core complex regulates dendrite and spine development in postmitotic neurons.The Journal of cell biology · 2005Article
- Expression of phosphatidylinositol (4,5) bisphosphate-specific pleckstrin homology domains alters direction but not the level of axonal transport of mitochondria.Molecular biology of the cell · 2003Article
- Actin filament-stabilizing protein tropomyosin regulates the size of dendritic fields.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Depletion of a microtubule-associated motor protein induces the loss of dendritic identity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Inhibition of dendrite formation in mouse melanocytes transiently transfected with antisense DNA to myosin Va.Journal of anatomy · 1999Article
- Nonuniform microtubular polarity established by CHO1/MKLP1 motor protein is necessary for process formation of podocytes.The Journal of cell biology · 1998Article
- A nematode kinesin required for cleavage furrow advancement.Current biology : CB · 1998Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Microtubules in the axon are uniformly oriented, while microtubules in the dendrite are nonuniformly oriented. We have proposed that these distinct microtubule polarity patterns may arise from a redistribution of molecular motor proteins previously used for mitosis of the developing neuroblast. To address this issue, we performed studies on neuroblastoma cells that undergo mitosis but also generate short processes during interphase. Some of these processes are similar to axons with regard to their morphology and microtubule polarity pattern, while others are similar to dendrites. Treatment with cAMP or retinoic acid inhibits cell division, with the former promoting the development of the axon-like processes and the latter promoting the development of the dendrite-like processes. During mitosis, the kinesin-related motor termed CHO1/MKLP1 is localized within the spindle midzone where it is thought to transport microtubules of opposite orientation relative to one another. During process formation, CHO1/ MKLP1 becomes concentrated within the dendrite-like processes but is excluded from the axon-like processes. The levels of CHO1/MKLP1 increase in the presence of retinoic acid but decrease in the presence of cAMP, consistent with a role for the protein in dendritic differentiation. Moreover, treatment of the cultures with antisense oligonucleotides to CHO1/MKLP1 compromises the formation of the dendrite-like processes. We speculate that a redistribution of CHO1/MKLP1 is required for the formation of dendrite-like processes, presumably by establishing their characteristic nonuniform microtubule polarity pattern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.