ArticleThe Journal of cell biology1997
A centromere DNA-binding protein from fission yeast affects chromosome segregation and has homology to human CENP-B.
Article in The Journal of cell biology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- Fungi as models of centromere innovation: from DNA sequence to 3-dimensional arrangement.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Review
- The fission yeast CENP-B protein Abp1 prevents pervasive transcription of repetitive DNA elements.Biochimica et biophysica acta · 2016Article
- Putative CENP-B paralogues are not present at mammalian centromeres.Chromosoma · 2012Article
- Article
- The fission yeast homologue of CENP-B, Abp1, regulates directionality of mating-type switching.The EMBO journal · 2008Article
- Convergent domestication of pogo-like transposases into centromere-binding proteins in fission yeast and mammals.Molecular biology and evolution · 2008Article
- Centromere size and position in Candida albicans are evolutionarily conserved independent of DNA sequence heterogeneity.Molecular genetics and genomics : MGG · 2007Article
- Mitotic chromosome biorientation in fission yeast is enhanced by dynein and a minus-end-directed, kinesin-like protein.Molecular biology of the cell · 2007Article
- The CENP-B homolog, Abp1, interacts with the initiation protein Cdc23 (MCM10) and is required for efficient DNA replication in fission yeast.Cell division · 2006Article
- Chromosome segregation in fission yeast with mutations in the tubulin folding cofactor D.Current genetics · 2006Article
- The role of heterochromatin in centromere function.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Tandemly repeated DNA sequences and centromeric chromosomal regions of Arabidopsis species.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2003Review
- The fission yeast ubiquitin-conjugating enzymes UbcP3, Ubc15, and Rhp6 affect transcriptional silencing of the mating-type region.Eukaryotic cell · 2002Article
- Fission yeast CENP-B homologs nucleate centromeric heterochromatin by promoting heterochromatin-specific histone tail modifications.Genes & development · 2002Article
- Functional redundancies, distinct localizations and interactions among three fission yeast homologs of centromere protein-B.Genetics · 2001Article
- Fission yeast homologs of human CENP-B have redundant functions affecting cell growth and chromosome segregation.Molecular and cellular biology · 2000Article
- Interspersed centromeric element with a CENP-B box-like motif in Chironomus pallidivittatus.Nucleic acids research · 1998Article
- The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha-tubulin.Nucleic acids research · 1998Article
- Structure of the chromosome VII centromere region in Neurospora crassa: degenerate transposons and simple repeats.Molecular and cellular biology · 1998Article
- Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights.The Journal of cell biology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Genetic and biochemical strategies have been used to identify Schizosaccharomyces pombe proteins with roles in centromere function. One protein, identified by both approaches, shows significant homology to the human centromere DNA-binding protein, CENP-B, and is identical to Abp1p (autonomously replicating sequence-binding protein 1) (Murakami, Y., J.A. Huberman, and J. Hurwitz. 1996. Proc. Natl. Acad. Sci. USA. 93:502-507). Abp1p binds in vitro specifically to at least three sites in centromeric central core DNA of S. pombe chromosome II (cc2). Overexpression of abp1 affects mitotic chromosome stability in S. pombe. Although inactivation of the abp1 gene is not lethal, the abp1 null strain displays marked mitotic chromosome instability and a pronounced meiotic defect. The identification of a CENP-B-related centromere DNA-binding protein in S. pombe strongly supports the hypothesis that fission yeast centromeres are structurally and functionally related to the centromeres of higher eukaryotes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.