ArticleThe Journal of physiology1997
Purinoceptor-operated cationic channels in human B lymphocytes.
Article in The Journal of physiology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- Two serial filters control P2X7 cation selectivity, Ser342 in the central pore and lateral acidic residues at the cytoplasmic interface.PNAS nexus · 2024Article
- Targeting the Adenosinergic Axis in Chronic Lymphocytic Leukemia: A Way to Disrupt the Tumor Niche?International journal of molecular sciences · 2018Review
- Regulation of the Immune Response by the Inflammatory Metabolic Microenvironment in the Context of Allotransplantation.Frontiers in immunology · 2018Review
- Purinergic signalling and immune cells.Purinergic signalling · 2014Review
- Large-conductance channel formation mediated by P2X7 receptor activation is regulated through distinct intracellular signaling pathways in peritoneal macrophages and 2BH4 cells.Naunyn-Schmiedeberg's archives of pharmacology · 2010Article
- The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism.Frontiers in bioscience : a journal and virtual library · 2008Review
- Activation kinetics of single P2X receptors.Purinergic signalling · 2007Article
- Influence of extracellular monovalent cations on pore and gating properties of P2X7 receptor-operated single-channel currents.Biophysical journal · 2007Article
- Kinetics of P2X7 receptor-operated single channels currents.Biophysical journal · 2007Article
- Chemotactic activity of extracellular nucleotideson human immune cells.Purinergic signalling · 2007Article
- P2X(7) receptor: Death or life?Purinergic signalling · 2005Article
- Article
- P2X7 receptor-mediated release of excitatory amino acids from astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Functional evidence of distinct ATP activation sites at the human P2X(7) receptor.The Journal of physiology · 2001Article
- P2X7 receptors in Müller glial cells from the human retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Two different ionotropic receptors are activated by ATP in rat microglia.The Journal of physiology · 1999Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Using the patch clamp method in the outside-out configuration, purinoceptor-dependent unitary currents were measured in tonsillar and transformed tonsillar human B lymphocytes. 2. Single channel currents were evoked by ATP4-, the free-acid form of ATP, and by 2',3' O-benzoyl-4-benzoyl-ATP (BzATP) in the micromolar concentration range, but not by 10 mM ADP3- or 0.5 mM Mg(2+)-bound ATP. 3. The channels could be activated and deactivated several times for as long as 30 min even in the absence of intracellular ATP, GTP, or glucose. 4. The channels were selective for small cations and had a conductance of 9 pS with Cs+ as the intracellular and Na+ as the extracellular monovalent cation. 5. The half-maximal activation of the channels was obtained by 114 microM ATP4- and by 16 microM BzATP. The increase in the open probability after raising the ATP4- concentration was mainly due to a decrease in the times the channels spend in the closed state. 6. It is concluded that human B lymphocytes possess cationic channels directly gated by extracellular ATP4-. Their agonist binding characteristics are typical for P2z purinoceptors, but their permeation behaviour is different from the large non-specific pores formed by ATP4- in fibroblasts, macrophages and mast cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.