ArticleJournal of bacteriology1997
Biological function of the dTDP-rhamnose synthesis pathway in Streptococcus mutans.
Article in Journal of bacteriology, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 118 citations in OpenAlex.
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- Genomic Differences between Listeria monocytogenes EGDe Isolates Reveal Crucial Roles for SigB and Wall Rhamnosylation in Biofilm Formation.Journal of bacteriology · 2020Article
- Streptococcal dTDP-L-rhamnose biosynthesis enzymes: functional characterization and lead compound identification.Molecular microbiology · 2019Article
- Genome Structure of the Opportunistic PathogenFrontiers in microbiology · 2018Article
- Does the eclipse limit bacterial nucleoid complexity and cell width?Synthetic and systems biotechnology · 2017Review
- Bacterial glycobiology: rhamnose-containing cell wall polysaccharides in Gram-positive bacteria.FEMS microbiology reviews · 2016Review
- L-Rhamnosylation of Listeria monocytogenes Wall Teichoic Acids Promotes Resistance to Antimicrobial Peptides by Delaying Interaction with the Membrane.PLoS pathogens · 2015Article
- The flagellin FliC of Clostridium difficile is responsible for pleiotropic gene regulation during in vivo infection.PloS one · 2014Article
- Oil degradation and biosurfactant production by the deep sea bacterium Dietzia maris As-13-3.Frontiers in microbiology · 2014Article
- Haloferax volcanii N-glycosylation: delineating the pathway of dTDP-rhamnose biosynthesis.PloS one · 2014Article
- Complete genome sequence of the serotype k Streptococcus mutans strain LJ23.Journal of bacteriology · 2012Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have cloned a new gene locus that comprises three genes concerned with the biosynthesis of the serotype c-specific polysaccharide antigen in Streptococcus mutans. The genes encode proteins exhibiting significant homology to the rfbA, rfbB, and rfbD gene products that are involved in the anabolism of dTDP-L-rhamnose from D-glucose-1-phosphate. This anabolism pathway pertains to biosynthesis of the O antigen of lipopolysaccharide in gram-negative bacteria. The cell extract of Escherichia coli expressing each of the cloned genes of S. mutans exhibited enzymatic activity corresponding to the homologous counterpart of the rfb gene products. Rhamnose was not detected in the cell wall preparation purified from the mutant in which each of the three cloned genes was insertionally inactivated. Rabbit antiserum against S. mutans serotype c-specific antigen did not react with the autoclaved extracts from these mutants. These results indicate that the gene products identified in the present study are involved in the dTDP-L-rhamnose synthesis pathway and that the pathway relates to the biosynthesis of the serotype-specific polysaccharide antigen of S. mutans. Southern hybridization analysis revealed that genes homologous to the cloned genes involved in the dTDP-L-rhamnose synthesis pathway were widely distributed in a variety of streptococci. This is the first report of the biological function of the dTDP-rhamnose pathway in streptococci.
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