ArticleNucleic acids research1997
A high affinity binding site for the HIV-1 nucleocapsid protein.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Rational design of self-assembled RNA nanostructures for HIV-1 virus assembly blockade.Nucleic acids research · 2022Article
- Retroviral nucleocapsid proteins and DNA strand transfers.Biochimie open · 2018Review
- Potential inhibition of HIV-1 encapsidation by oligoribonucleotide-dendrimer nanoparticle complexes.International journal of nanomedicine · 2017Article
- Article
- The in vitro loose dimer structure and rearrangements of the HIV-2 leader RNA.Nucleic acids research · 2011Article
- HIV-1 nucleocapsid protein increases strand transfer recombination by promoting dimeric G-quartet formation.The Journal of biological chemistry · 2011Article
- Identification of a methylated oligoribonucleotide as a potent inhibitor of HIV-1 reverse transcription complex.Nucleic acids research · 2011Article
- Design of single-stranded nucleic acid binding peptides based on nucleocapsid CCHC-box zinc-binding domains.Journal of the American Chemical Society · 2010Article
- Analysis of human immunodeficiency virus type 1 vector cis- and trans-acting elements production by means of Semliki Forest virus.Gene therapy · 2009Article
- Retroviral nucleocapsid proteins display nonequivalent levels of nucleic acid chaperone activity.Journal of virology · 2008Article
- Single-molecule FRET studies of important intermediates in the nucleocapsid-protein-chaperoned minus-strand transfer step in HIV-1 reverse transcription.Biophysical journal · 2005Article
- Unfolding of DNA quadruplexes induced by HIV-1 nucleocapsid protein.Nucleic acids research · 2005Article
- Basic residues of the retroviral nucleocapsid play different roles in gag-gag and Gag-Psi RNA interactions.Journal of virology · 2004Article
- A structural linkage between the dimerization and encapsidation signals in HIV-2 leader RNA.RNA (New York, N.Y.) · 2003Article
- RNA structure and packaging signals in the 5' leader region of the human immunodeficiency virus type 1 genome.Journal of virology · 2002Article
- Mapping the encapsidation determinants of feline immunodeficiency virus.Journal of virology · 2002Article
- Mutations that confer resistance to template-analog inhibitors of human immunodeficiency virus (HIV) type 1 reverse transcriptase lead to severe defects in HIV replication.Journal of virology · 2002Article
- Sequence-specific interaction between HIV-1 matrix protein and viral genomic RNA revealed by in vitro genetic selection.RNA (New York, N.Y.) · 2001Article
- Characterization of Rous sarcoma virus Gag particles assembled in vitro.Journal of virology · 2001Article
- A heterologous, high-affinity RNA ligand for human immunodeficiency virus Gag protein has RNA packaging activity.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The nucleocapsid protein (NC) of HIV-1 is a small zinc finger protein that contributes to multiple steps of the viral life cycle, including the proper encapsidation of HIV RNA. This is accomplished through an interaction between NC and a region at the 5'-end of the RNA, defined as the Psi element. However, the specificity of NC for Psi or for RNA in general is not well understood. To study this problem, we used SELEX to identify high affinity RNA ligands that bind to NC. A 'winner' molecule (SelPsi), as well as a subregion of Psi RNA, were further characterized to understand the interaction between NC and SelPsi and its relationship to the interaction between NC and Psi. The comparison makes predictions about the sequence and structure of a high affinity binding site within the HIV-1 Psi element.
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