ArticleNucleic acids research1997
Mammalian cDNA and prokaryotic reporter sequences silence adjacent transgenes in transgenic mice.
Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Multiple expression cassette exchange via TP901-1, R4, and Bxb1 integrase systems on a mouse artificial chromosome.FEBS open bio · 2017Article
- The growth and reproduction performance of TALEN-mediated β-lactoglobulin-knockout bucks.Transgenic research · 2016Article
- Development of a transgenic mouse model with immune tolerance for human coagulation factor VIIa.Pharmaceutical research · 2013Article
- A site-specific recombinase-based method to produce antibiotic selectable marker free transgenic cattle.PloS one · 2013Article
- Genetically Engineered Mice by Pronuclear DNA microinjection.Current protocols in mouse biology · 2012Article
- Primary transgenic bovine cells and their rejuvenated cloned equivalents show transgene-specific epigenetic differences.PloS one · 2012Article
- A method for producing transgenic cells using a multi-integrase system on a human artificial chromosome vector.PloS one · 2011Article
- Transgene design.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Laser-evoked synaptic transmission in cultured hippocampal neurons expressing channelrhodopsin-2 delivered by adeno-associated virus.Journal of neuroscience methods · 2009Article
- Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.Molecular and cellular biology · 2008Article
- Stringent and reproducible tetracycline-regulated transgene expression by site-specific insertion at chromosomal loci with pre-characterised induction characteristics.BMC molecular biology · 2007Article
- Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control.PLoS biology · 2004Article
- On the use of post-transcriptional processing elements in transgenes.Transgenic research · 2004Article
- A new beta-lactoglobulin-based vector targets luciferase cDNA expression to the mammary gland of transgenic mice.Transgenic research · 2001Article
- Article
- The mammary gland as a bioreactor: expression, processing, and production of recombinant proteins.Journal of mammary gland biology and neoplasia · 1998Review
- Epigenetic transcriptional silencing and 5-azacytidine-mediated reactivation of a complex transgene in rice.Plant physiology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ovine beta-lactoglobulin gene is expressed efficiently and at high levels in the mammary gland of transgenic mice. In contrast, when this gene is linked to a second gene construct comprising a mammalian cDNA or a CAT reporter sequence it fails to be expressed in the majority of transgenic lines generated. We suggest that mammalian cDNAs and prokaryotic reporter sequences can serve as active foci for gene silencing in the mammalian genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.