Evidence map›Paper›PMID 9023111›Full record

ArticleNucleic acids research1997

The fission yeast UVDR DNA repair pathway is inducible.

S Davey, M L Nass, J V Ferrer, K Sidik, A Eisenberger, D L Mitchell, G A Freyer

Open access · bronzeAbstract read
In one paragraph

Article in Nucleic acids research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

S DaveyCancer Research Laboratories, Queen's University, Kingston, Canada K7L 3N6.
M L Nass
J V Ferrer
K Sidik
A Eisenberger
D L Mitchell
G A Freyer
Columbia University · USQueen's University · CAGenesis Foundation · USUniversity of Malaya · MY

Funding

NEW DNA REPAIR PATHWAY FOR CARCINOGENIC UV ADDUCTSR01CA072647 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FREYER, GREG A · 1996 to 2005
$1.5M
NCI NIH HHS CA72647NIEHS NIH HHS ES05914
6 · The paper itself

Abstract

In addition to nucleotide excision repair (NER), the fission yeast Schizosaccharomyces pombe possesses a UV damage endonuclease (UVDE) for the excision of cyclobutane pyrimidine dimers and 6-4 pyrimidine pyrimidones. We have previously described UVDE as part of an alternative excision repair pathway, UVDR, for UV damage repair. The existence of two excision repair processes has long been postulated to exist in S.pombe, as NER-deficient mutants are still proficient in the excision of UV photoproducts. UVDE recognizes the phosphodiester bond immediately 5'of the UV photoproducts as the initiating event in this process. We show here that UVDE activity is inducible at both the level of uve1+ mRNA and UVDE enzyme activity. Further, we show that UVDE activity is regulated by the product of the rad12 gene.

Indexed as

DNA RepairSchizosaccharomyces pombe ProteinsUltraviolet RaysBase SequenceCell CycleDNA DamageDNA, FungalEndodeoxyribonucleasesEnzyme InductionGenes, FungalMolecular Sequence DataPromoter Regions, GeneticRNA, MessengerSchizosaccharomycesDNA, FungalEndodeoxyribonucleasesRNA, MessengerSchizosaccharomyces pombe Proteinsuve1 protein, S pombe

Identifiers

PMID9023111
PMCPMC146545
OpenAlexW2102411358

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.