ArticleThe Journal of clinical investigation1997
Alternative expression of platelet glycoprotein Ib(beta) mRNA from an adjacent 5' gene with an imperfect polyadenylation signal sequence.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 63 citations in OpenAlex.
- Hemizygosity for the gene encoding glycoprotein Ibβ is not responsible for macrothrombocytopenia and bleeding in patients with 22q11 deletion syndrome.Journal of thrombosis and haemostasis : JTH · 2019Article
- Article
- The Mammalian Septin Interactome.Frontiers in cell and developmental biology · 2017Review
- Septin functions in organ system physiology and pathology.Biological chemistry · 2014Review
- Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease.The American journal of pathology · 2008Article
- Human septin-septin interactions as a prerequisite for targeting septin complexes in the cytosol.The Biochemical journal · 2004Article
- A prototypic platelet septin and its participation in secretion.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- The septin CDCrel-1 is dispensable for normal development and neurotransmitter release.Molecular and cellular biology · 2002Article
- Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene.Genome research · 2000Article
- MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25).Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- Identification of septins in neurofibrillary tangles in Alzheimer's disease.The American journal of pathology · 1998Article
- t(11;22)(q23;q11.2) In acute myeloid leukemia of infant twins fuses MLL with hCDCrel, a cell division cycle gene in the genomic region of deletion in DiGeorge and velocardiofacial syndromes.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Comparative mapping of the DiGeorge syndrome region in mouse shows inconsistent gene order and differential degree of gene conservation.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- The mouse pale ear (ep) mutation is the homologue of human Hermansky-Pudlak syndrome.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Glycoprotein (GP) Ib is a major component of the platelet membrane receptor for von Willebrand factor, designated the GP Ib-IX-V complex. GP Ib is composed of two subunits (GP Ib(alpha) and GP Ib(beta)) each synthesized from separate genes. The 206 amino acid precursor of GP Ib(beta) is synthesized from a 1.0-kb mRNA expressed by megakaryocytes and was originally characterized from cDNA clones of human erythroleukemic (HEL) cell mRNA, a cell line exhibiting megakaryocytic-like properties. The cell line CHRF-288-11 also exhibits megakaryocytic-like properties, but synthesizes two related GP Ib(beta) mRNA species of 3.5 and 1.0 kb. We performed cDNA cloning experiments to identify the origin of the 3.5-kb transcript and determine its relationship to the 1.0-kb GP Ib(beta) mRNA found in megakaryocytes, platelets, and HEL cells. Our cloning experiments demonstrate that the longer transcript results from a nonconsensus polyadenylation recognition sequence, 5'AACAAT3', within a separate gene located upstream to the platelet GP Ib(beta) gene. In the absence of normal polyadenylation the more 5' gene uses the polyadenylation site within its 3' neighbor, the platelet GP Ib(beta) gene. This newly identified 5' gene contains an open reading frame encoding 369 amino acids with a high degree of sequence similarity to an expanding family of GTP-binding proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.