ArticleThe Journal of clinical investigation1997
Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 111 citations in OpenAlex.
- Guideline
- Determination of the structural, electronic, optoelectronic and thermodynamic properties of the methylxanthine molecules theophylline and theobromine.Optical and quantum electronics · 2020Article
- Caffeine to prevent respiratory failure and improve outcome in infant pertussis.BMJ case reports · 2018Article
- Peripheral neural circuitry in cough.Current opinion in pharmacology · 2015Review
- Antitussive drugs--past, present, and future.Pharmacological reviews · 2014Review
- Article
- KCa1.1 channel contributes to cell excitability in unmyelinated but not myelinated rat vagal afferents.American journal of physiology. Cell physiology · 2011Article
- Targeting peripheral afferent nerve terminals for cough and dyspnea.Current opinion in pharmacology · 2011Review
- TRPA1 agonists evoke coughing in guinea pig and human volunteers.American journal of respiratory and critical care medicine · 2009Article
- Central regulation of the cough reflex: therapeutic implications.Pulmonary pharmacology & therapeutics · 2009Review
- Peripheral mechanisms II: the pharmacology of peripherally active antitussive drugs.Handbook of experimental pharmacology · 2009Review
- Sensory nerves and airway irritability.Handbook of experimental pharmacology · 2009Review
- Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways.British journal of pharmacology · 2008Article
- Review
- Encoding of the cough reflex.Pulmonary pharmacology & therapeutics · 2007Review
- Chronic cough due to occupational factors.Journal of occupational medicine and toxicology (London, England) · 2006Article
- Identification and functional characterization of ankyrin-repeat family protein ANKRA as a protein interacting with BKCa channel.Molecular biology of the cell · 2005Article
- Review
- Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation.British journal of pharmacology · 2003Article
- Pharmacology of airway afferent nerve activity.Respiratory research · 2001Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Sensory nerves play an important role in airway disease by mediating central reflexes such as cough, and local axon reflexes resulting in the peripheral release of neuropeptides. We have tested whether the benzimidazolone compound, NS1619, an opener of large conductance calcium-activated potassium (BK Ca) channels, inhibits the activity of sensory fibers, and central and local airway reflexes in guinea pig airways. In in vitro single fiber recording experiments, NS1619 applied to identified receptive fields in the trachea inhibited the firing of A(delta)-fibers evoked by hypertonic saline and distilled water, and bradykinin-evoked firing of C-fibers. Electrically evoked nonadrenergic noncholinergic contractions of isolated bronchi mediated by the release of neurokinin A (NKA) from C-fibers, but not those elicited by exogenous NKA, were inhibited by NS1619. These effects of NS1619 were prevented by iberiotoxin, a selective blocker of BK Ca channels. In conscious guinea pigs, cough evoked by aerosolized citric acid was also inhibited by NS1619. These data show that BK Ca channel activation inhibits sensory nerve activity, resulting in a reduction of both afferent and efferent function. BK Ca channel openers may therefore be of potential benefit in reducing neurogenic inflammation and central reflexes seen during inflammatory conditions of the airways, and may represent a new class of antitussive drug.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.