ArticleThe Journal of clinical investigation1997
Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2.
Article in The Journal of clinical investigation, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 161 citations in OpenAlex.
- Interleukin-18 in metabolism: From mice physiology to human diseases.Frontiers in endocrinology · 2022Review
- Association between IL-18 gene polymorphisms and Hashimoto thyroiditis.Molecular biology reports · 2021Article
- 100 years post-insulin: immunotherapy as the next frontier in type 1 diabetes.Immunotherapy advances · 2021Review
- Inflammasomes and Type 1 Diabetes.Frontiers in immunology · 2021Review
- Article
- Expression of mRNA and protein of IL-18 and its receptor in human follicular granulosa cells.Journal of endocrinological investigation · 2017Article
- Association of the interleukin-18 -137 C/G, -607 A/C polymorphisms with type 1 diabetes: A meta-analysis.Biomedical reports · 2014Article
- IL-18 in inflammatory and autoimmune disease.Cellular and molecular life sciences : CMLS · 2013Review
- IL-18 is required for self-reactive T cell expansion in NOD mice.Journal of autoimmunity · 2011Article
- Thyrocyte interleukin-18 expression is up-regulated by interferon-γ and may contribute to thyroid destruction in Hashimoto's thyroiditis.International journal of experimental pathology · 2010Article
- IL-18 105 A>C polymorphism contributes to renal manifestations in patients with SLE.Rheumatology international · 2009Article
- Genetic control of severe egg-induced immunopathology and IL-17 production in murine schistosomiasis.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Association of single nucleotide polymorphisms in the IL-18 gene with production of IL-18 protein by mononuclear cells from healthy donors.Mediators of inflammation · 2008Article
- Interleukin-18 enhances glucose uptake in 3T3-L1 adipocytes.Endocrine · 2007Article
- Interleukin-18 genetics and inflammatory disease susceptibility.Genes and immunity · 2007Review
- Interleukin-12 to interleukin 'infinity': the rationale for future therapeutic cytokine targeting.Springer seminars in immunopathology · 2006Review
- Interleukin 18 promoter polymorphisms are not strongly associated with type I diabetes in a UK population.Genes and immunity · 2005Article
- Elevated interleukin-18 levels correlated with disease activity in systemic lupus erythematosus.Clinical rheumatology · 2004Article
- IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune disease.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Role of cytokines in the pathogenesis of autoimmune diabetes mellitus.Reviews in endocrine & metabolic disorders · 2003Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, interferon-gamma-inducing-factor (IGIF) has been described as a novel monokine that is a more potent interferon-gamma (IFN-gamma) inducer than IL-12. By cloning IGIF from affected tissue and studying IGIF gene expression, we describe for the first time a close association of this cytokine with an autoimmune disease. The non-obese diabetic (NOD) mouse spontaneously develops autoimmune insulitis and diabetes which can be accelerated and synchronized by a single injection of cyclophosphamide. IGIF mRNA was demonstrated by reverse transcriptase PCR in NOD mouse pancreas during early stages of insulitis. Levels of IGIF mRNA increased rapidly after cyclophosphamide treatment and preceded a rise in IFN-gamma mRNA, and subsequently diabetes. Interestingly, these kinetics mimick that of IL-12p40 mRNA, resulting in a close correlation of individual mRNA levels. Cloning of the IGIF cDNA from pancreas RNA followed by sequencing revealed identity with the IGIF sequence cloned from Kupffer cells and in vivo preactivated macrophages. When extending our study to macrophages of the spleen we observed that NOD mouse macrophages responded to cyclophosphamide with IGIF gene expression while macrophages from Balb/c mice treated in parallel did not. The IGIF gene position is located within the Idd2 interval on mouse chromosome 9 and therefore it is a candidate for the Idd2 susceptible gene. We conclude that IGIF expression is abnormally regulated in autoimmune NOD mice and closely associated with diabetes development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.