ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
Structure and expression of the mouse casein gene locus.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 41 citations in OpenAlex.
- Casein Gene Cluster in Camelids: Comparative Genome Analysis and New Findings on Haplotype Variability and Physical Mapping.Frontiers in genetics · 2019Article
- Differential expression of genes in milk of dairy cattle during lactation.Animal genetics · 2016Article
- Functional development of the adult ovine mammary gland--insights from gene expression profiling.BMC genomics · 2015Article
- An odor timer in milk? Synchrony in the odor of milk effluvium and neonatal chemosensation in the mouse.PloS one · 2012Article
- The contribution of adhesion signaling to lactogenesis.Journal of cell communication and signaling · 2010Article
- Epigenetic modifications in 3D: nuclear organization of the differentiating mammary epithelial cell.Journal of mammary gland biology and neoplasia · 2010Review
- Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function.The Journal of cell biology · 2009Article
- Onset of lactation in the bovine mammary gland: gene expression profiling indicates a strong inhibition of gene expression in cell proliferation.Functional & integrative genomics · 2008Article
- Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors.The Journal of biological chemistry · 2007Article
- Contrasting models of promiscuous gene expression by thymic epithelium.The Journal of experimental medicine · 2005Review
- Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels.The Journal of experimental medicine · 2005Article
- Multispecies comparison of the casein gene loci and evolution of casein gene family.Journal of mammary gland biology and neoplasia · 2002Review
- Physical map and localization of the human casein gene locus.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
- Organization of the bovine casein gene locus.Mammalian genome : official journal of the International Mammalian Genome Society · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The analysis of yeast artificial chromosomes (YACs) containing the complete mouse casein gene locus revealed the presence of five casein genes, alpha-, beta-, gamma-, delta-, and kappa-casein, in this order, in the locus. The alpha- and beta-casein genes are only 10 kb apart and have convergent transcriptional orientations. The distance between the beta-casein gene and the alpha s2-like gamma-casein gene is about 70 kb, and these genes have divergent transcriptional orientations. The gamma- and delta-casein genes, both encoding a alpha s2-like casein, are linked within 60 kb and convergently transcribed. The kappa-casein gene is located about 100 kb from the delta-gene. Except for the presence of the delta-casein gene, the organization of the mouse casein locus resembles that of the bovine locus, including the transcriptional orientation of the genes. In contrast to the other casein genes, which are strongly induced at mid-lactation, expression of the delta-casein gene is abruptly induced upon parturition. Comparative analysis of alpha s2-like sequences from various species suggests that the ancestral alpha s2-like gene duplicated around the time of radiation of the rodent and artiodactylid ancestors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.