ArticleMammalian genome : official journal of the International Mammalian Genome Society1997
Characterization of the mouse neutrophil elastase gene and localization to chromosome 10.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia.Scientific reports · 2021Article
- Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia.Frontiers in immunology · 2018Article
- SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G.Blood · 2013Article
- The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases.The Journal of biological chemistry · 2009Article
- Neutrophil serine proteases fine-tune the inflammatory response.The international journal of biochemistry & cell biology · 2008Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Neutrophil elastase (NE), a serine proteinase, is considered to play a role in normal tissue turnover and host defense, NE may also cause tissue damage in acute and chronic inflammatory diseases. We have isolated and characterized the gene for mouse NE and determined its chromosomal location. The mouse NE gene has been localized by interspecific backcross analysis to Chromosome (Chr) 10. The gene for mouse NE is composed of 5 exons and 4 introns, similar to the human NE. Mouse NE shares the highly conserved exon size and intron-exon borders with human NE. The coding exons of the mouse NE gene predict a translation product in a pre-pro form, similar to human NE. Knowledge of the genomic organization and chromosomal location of mouse NE may allow us to further define mechanisms responsible for cell and tissue-specific expression of mouse NE.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.