ArticleBritish journal of cancer1997
Bcl-2 expression and response to chemotherapy in colorectal adenocarcinomas.
Article in British journal of cancer, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 48 citations in OpenAlex.
- Bax expression is a candidate prognostic and predictive marker of colorectal cancer.Journal of gastrointestinal oncology · 2010Article
- AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.Radiation oncology (London, England) · 2009Article
- [Current status of the prognostic value of molecular markers in patients with colorectal cancer and the prediction of response to adjuvant therapy].Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2005Review
- Genetic factors influencing pyrimidine-antagonist chemotherapy.The pharmacogenomics journal · 2005Review
- Prognostic significance and correlation with survival of bcl-2 and TGF-beta RII in colon cancer.Digestive diseases and sciences · 2003Article
- [Clinical, pathological and molecular prognostic factors in colorectal carcinomas].Der Pathologe · 2003Review
- Tumour markers of prognosis in colorectal cancer.British journal of cancer · 1999Article
- Bcl-2 protein expression: association with p53 and prognosis in colorectal cancer.British journal of cancer · 1998Article
- Immunohistochemical detection of p53 and Bcl-2 in colorectal carcinoma: no evidence for prognostic significance.British journal of cancer · 1998Article
- Loss of Bcl-2 in invasive breast cancer is associated with high rates of cell death, but also with increased proliferative activity.British journal of cancer · 1998Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last year, a number of studies have reported the expression of bcl-2 in colorectal adenocarcinomas. However, the influence of bcl-2 expression on response to chemotherapy and outcome in patients with advanced colorectal adenocarcinoma has not been reported. We analysed bcl-2 expression in 231 colorectal tumours from patients that were treated by surgery alone or with 5-fluorouracil-based chemotherapy. Of 231 tumours, 149 (64.5%) overexpressed bcl-2. Bcl-2 expression was associated with low plasma CEA levels (P=0.013) and inversely associated with poor differentiation (P=0.049). However, bcl-2 expression did not significantly influence failure-free or overall survival in surgically treated patients. In the group of patients receiving 5-fluorouracil-based chemotherapy bcl-2 expression did not influence response to chemotherapy; nor did it effect failure-free or overall survival.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.