ArticleBritish journal of cancer1997
Apoptosis, cell proliferation and expression of Bcl-2 and Bax in gastric carcinomas: immunohistochemical and clinicopathological study.
Article in British journal of cancer, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bcl-2 expression and patient survival in gastric cancer: a systematic review of the literature with meta-analysis.Medical oncology (Northwood, London, England) · 2015Pooled it
- What Is Apoptosis and Why Is It Inhibited by the Most Important Tumor Suppressor (p53)?International journal of molecular sciences · 2025Review
- Regulation of Human Lung Adenocarcinoma Cell Proliferation by LncRNA AFAP-AS1 Through the miR-508/ZWINT Axis.International journal of molecular sciences · 2025Article
- Anastasis and Other Apoptosis-Related Prosurvival Pathways Call for a Paradigm Shift in Oncology: Significance of Deintensification in Treating Solid Tumors.International journal of molecular sciences · 2025Review
- Hijacking homeostasis: Regulation of the tumor microenvironment by apoptosis.Immunological reviews · 2023Review
- Article
- The Apoptosis Paradox in Cancer.International journal of molecular sciences · 2022Review
- Effect of selective inhibition of aquaporin 1 on chemotherapy sensitivity of J82 human bladder cancer cells.Oncology letters · 2018Article
- An apoptosis-driven 'onco-regenerative niche': roles of tumour-associated macrophages and extracellular vesicles.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- NLRP6, decreased in gastric cancer, suppresses tumorigenicity of gastric cancer cells.Cancer management and research · 2018Article
- Biomarkers for gastric cancer: Progression in early diagnosis and prognosis (Review).Oncology letters · 2015Article
- The expression of Bcl-2 and BID in gastric cancer cells.Journal of immunology research · 2014Article
- The role and prognostic value of apoptosis in colorectal carcinoma.BMC clinical pathology · 2013Article
- Depressed type of intramucosal differentiated-type gastric cancer has high cell proliferation and reduced apoptosis compared with the elevated type.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2013Article
- The effects of exogenous melatonin on the morphology of thyrocytes in pinealectomized and irradiated rats.Journal of neural transmission (Vienna, Austria : 1996) · 2006Article
- Potential role of bcl-2 and ki-67 expression and apoptosis in colorectal carcinoma: a clinicopathologic study.Digestive diseases and sciences · 2003Article
- Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas.British journal of cancer · 2002Article
- Increased apoptosis associated with depressed type of early intestinal gastric cancer.Japanese journal of cancer research : Gann · 2001Article
- Apoptosis in squamous cell carcinoma of the lung: correlation with survival and clinicopathological features.Journal of clinical pathology · 2001Article
- Early apoptosis in intestinal and diffuse gastric carcinomas.World journal of gastroenterology · 2000Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To clarify the relation between bcl-2 and bax protein (Bcl-2 and Bax) expression with regard to apoptosis and cell proliferation, 82 gastric carcinomas were immunohistochemically investigated. The significance of apoptosis for biological behaviour of the tumours was also examined. The apoptotic indices (AIs) were significantly lower in early-stage than in advanced-stage lesions (P<0.05), being positively correlated with the mitotic indices (MIs) (r=0.447, P<0.001). No association between either AIs or MIs and tumour size (diameter of intramural spreading) was noted. The AIs in the high Bcl-2-immunoreactive score group were significantly smaller than in either the low or the negative categories, whereas they were relatively elevated in the high Bax score group. In addition, an inverse correlation between Bcl-2 and Bax expression was revealed for both AIs and MIs. Although depth of tumour invasion and lymph node status were clearly associated with favourable outcome, no relation between survival rates and average values of either AIs or MIs, or immunoreactive scores for Bcl-2 and Bax was observed. These results indicate that in gastric carcinomas, apoptosis is closely associated with cell proliferation and expression of Bcl-2 and Bax, but appears likely to have no particular biological significance as a prognostic factor.
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