ArticleMolecular biology of the cell1997
Yeast counterparts of subunits S5a and p58 (S3) of the human 26S proteasome are encoded by two multicopy suppressors of nin1-1.
Article in Molecular biology of the cell, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 94 citations in OpenAlex.
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- Exploring disease-causing traits for drug repurposing in critically ill COVID-19 patients: A causal inference approach.iScience · 2023Article
- Defects in Mitochondrial Functions Affect the Survival of Yeast Cells Treated with Non-Thermal Plasma.International journal of molecular sciences · 2023Article
- The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.G3 (Bethesda, Md.) · 2013Article
- A proteasome assembly defect in rpn3 mutants is associated with Rpn11 instability and increased sensitivity to stress.Journal of molecular biology · 2011Article
- Article
- Proteasome substrate degradation requires association plus extended peptide.The EMBO journal · 2007Article
- Inositol deacylation by Bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins.Molecular biology of the cell · 2006Article
- Getting into position: the catalytic mechanisms of protein ubiquitylation.The Biochemical journal · 2004Review
- The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome.The EMBO journal · 2003Article
- The pleiotropic role of the 26S proteasome subunit RPN10 in Arabidopsis growth and development supports a substrate-specific function in abscisic acid signaling.The Plant cell · 2003Article
- Budding yeast Dsk2p is a polyubiquitin-binding protein that can interact with the proteasome.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Identification of virulence mutants of the fungal pathogen Cryptococcus neoformans using signature-tagged mutagenesis.Genetics · 2001Article
- A nonproteolytic function of the proteasome is required for the dissociation of Cdc2 and cyclin B at the end of M phase.Genes & development · 2000Article
- Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes.The EMBO journal · 2000Article
- Rpn9 is required for efficient assembly of the yeast 26S proteasome.Molecular and cellular biology · 1999Article
- Functional characterization of rpn3 uncovers a distinct 19S proteasomal subunit requirement for ubiquitin-dependent proteolysis of cell cycle regulatory proteins in budding yeast.Molecular and cellular biology · 1999Article
- Pleiotropic defects caused by loss of the proteasome-interacting factors Rad23 and Rpn10 of Saccharomyces cerevisiae.Genetics · 1999Article
- Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets.Genes & development · 1999Article
- Functional analysis of the proteasome regulatory particle.Molecular biology reports · 1999Review
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nin1p, a component of the 26S proteasome of Saccharomyces cerevisiae, is required for activation of Cdc28p kinase at the G1-S-phase and G2-M boundaries. By exploiting the temperature-sensitive phenotype of the nin1-1 mutant, we have screened for genes encoding proteins with related functions to Nin1p and have cloned and characterized two new multicopy suppressors, SUN1 and SUN2, of the nin1-1 mutation. SUN1 can suppress a null nin1 mutation, whereas SUN2, an essential gene, does not. Sun1p is a 268-amino acid protein which shows strong similarity to MBP1 of Arabidopsis thaliana, a homologue of the S5a subunit of the human 26S proteasome. Sun1p binds ubiquitin-lysozyme conjugates as do S5a and MBP1. Sun2p (523 amino acids) was found to be homologous to the p58 subunit of the human 26S proteasome. cDNA encoding the p58 component was cloned. Furthermore, expression of a derivative of p58 from which the N-terminal 150 amino acids had been removed restored the function of a null allele of SUN2. During glycerol density gradient centrifugation, both Sun1p and Sun2p comigrated with the known proteasome components. These results, as well as other structural and functional studies, indicate that both Sun1p and Sun2p are components of the regulatory module of the yeast 26S proteasome.
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