ArticleBiophysical journal1997
The binomial model in fluctuation analysis of quantal neurotransmitter release.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Selective, genetically induced increase in synaptic vesicle priming.Science advances · 2026Article
- Interpretation of presynaptic phenotypes of synaptic plasticity in terms of a two-step priming process.The Journal of general physiology · 2024Article
- Variance analysis as a method to predict the locus of plasticity at populations of non-uniform synapses.Frontiers in cellular neuroscience · 2023Article
- Article
- Probabilities of evoked and spontaneous synaptic transmission at individual active zones: Lessons fromFrontiers in molecular neuroscience · 2022Review
- Short-Term Synaptic Plasticity: Microscopic Modelling and (Some) Computational Implications.Advances in experimental medicine and biology · 2022Article
- Incomplete vesicular docking limits synaptic strength under high release probability conditions.eLife · 2020Article
- A Practical Guide to Using CV Analysis for Determining the Locus of Synaptic Plasticity.Frontiers in synaptic neuroscience · 2020Article
- Developmental Increase of Neocortical Presynaptic EfficacyFrontiers in synaptic neuroscience · 2019Article
- Two Forms of Synaptic Depression Produced by Differential Neuromodulation of Presynaptic Calcium Channels.Neuron · 2018Article
- A two-step docking site model predicting different short-term synaptic plasticity patterns.The Journal of general physiology · 2018Article
- Transmission of temporally correlated spike trains through synapses with short-term depression.PLoS computational biology · 2018Article
- Modelling the response to low-frequency repetitive nerve stimulation of myasthenia gravis and Lambert-Eaton myasthenic syndrome.Medical & biological engineering & computing · 2016Article
- Prefrontal Cortex to Accumbens Projections in Sleep Regulation of Reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Counting Vesicular Release Events Reveals Binomial Release Statistics at Single Glutamatergic Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Extracting quantal properties of transmission at central synapses.Neuromethods · 2016Article
- Developmental tightening of cerebellar cortical synaptic influx-release coupling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Paired-pulse facilitation at recurrent Purkinje neuron synapses is independent of calbindin and parvalbumin during high-frequency activation.The Journal of physiology · 2013Article
- Theoretical models of synaptic short term plasticity.Frontiers in computational neuroscience · 2013Article
- Mathematical analysis and algorithms for efficiently and accurately implementing stochastic simulations of short-term synaptic depression and facilitation.Frontiers in computational neuroscience · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mathematics of the binomial model for quantal neurotransmitter release is considered in general terms, to explore what information might be extractable from statistical aspects of data. For an array of N statistically independent release sites, each with a release probability p, the compound binomial always pertains, with <m> = N<p>, p' identical to 1 - var(m)/<m> = <p> (1 + cvp2) and n' identical to <m>/p' = N/(1 + cvp2), where m is the output/stimulus and cvp2 is var(p)/<p>2. Unless n' is invariant with ambient conditions or stimulation paradigms, the simple binomial (cvp = 0) is untenable and n' is neither N nor the number of "active" sites or sites with a quantum available. At each site p = popA, whereas po is the output probability if a site is "eligible" or "filled" despite previous quantal discharge, and pA (eligibility probability) depends at least on the replenishment rate, po, and interstimulus time. Assuming stochastic replenishment, a simple algorithm allows calculation of the full statistical composition of outputs for any hypothetical combinations of po's and refill rates, for any stimulation paradigm and spontaneous release. A rise in n' (reduced cvp) tends to occur whenever po varies widely between sites, with a raised stimulation frequency or factors (tending to increase po's. Unlike <m> and var(m) at equilibrium, output changes early in trains of stimuli, and covariances, potentially provide information about whether changes in <m> reflect change in <po> or in <pA>. Formulae are derived for variance and third moments of postsynaptic responses, which depend on the quantal mix in the signals. A new, easily computed function, the area product, gives noise-unbiased variance of a series of synaptic signals and its peristimulus time distribution, which is modified by the unit channel composition of quantal responses and if the signals reflect mixed responses from synapses with different quantal time course.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.