ArticleBiophysical journal1997
A mechanism for discharge of charged excitatory neurotransmitter.
Article in Biophysical journal, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Hydrodynamic flow in a synaptic cleft during exocytosis.European biophysics journal : EBJ · 2012Article
- Vesicular release of glutamate utilizes the proton gradient between the vesicle and synaptic cleft.Frontiers in synaptic neuroscience · 2010Article
- The effects of vesicular volume on secretion through the fusion pore in exocytotic release from PC12 cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Artificial cells: unique insights into exocytosis using liposomes and lipid nanotubes.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excitatory neurotransmitter is charged, so that emptying of a transmitter-containing vesicle (discharge) would seem to require considerable energy. Even if the energy problem is surmounted and discharge thereby made possible, there is still a problem of making the discharge fast enough (considerably less than 1 ms). Proposed here is a mechanism wherein discharge of charged transmitter is accompanied by the influx of cocharged ions or coefflux of counter-charged particles (ion interchange). It is shown theoretically that ion interchange obviates the necessity for a separate energy source and can provide the observed rapid vesicle discharge.
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Registered trials
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