ArticleThe Journal of experimental medicine1997
Estrogen protects lenses against cataract induced by transforming growth factor-beta (TGFbeta).
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Pooled it
- Aging of Nonhuman Primate Eyes Is Sexually Dimorphic.Investigative ophthalmology & visual science · 2026Article
- Global burden for blindness and vision loss among women of childbearing age and perimenopause: age-period-cohort analysis 2021.Scientific reports · 2026Article
- Gender differences in the burden of near vision loss in China: An analysis based on GBD 2021 data.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Article
- Association of Alpha-Crystallin with Human Cortical and Nuclear Lens Lipid Membrane Increases with the Grade of Cortical and Nuclear Cataract.International journal of molecular sciences · 2024Article
- Trends in the global burden of vision loss among the older adults from 1990 to 2019.Frontiers in public health · 2024Article
- Sex differences in symptom presentation and their impact on diagnostic accuracy in Werner syndrome.Geriatrics & gerontology international · 2024Article
- Hysterectomy for Benign Indications and Risk of Cataract Formation in South Korean Women.Medicina (Kaunas, Lithuania) · 2023Article
- Sex Hormones and Their Effects on Ocular Disorders and Pathophysiology: Current Aspects and Our Experience.International journal of molecular sciences · 2022Review
- Investigation of expression and effects of TGF-β1 and MMP-9 in lens epithelial cells of diabetic cataract rats.Experimental and therapeutic medicine · 2019Article
- Efficacy of Intravitreal injection of 2-Methoxyestradiol in regression of neovascularization of a retinopathy of prematurity rat model.BMC ophthalmology · 2017Article
- Development of topical ophthalmic In Situ gel-forming estradiol delivery system intended for the prevention of age-related cataracts.PloS one · 2017Article
- Estrogen mediated protection of cytoskeleton against oxidative stress.The Indian journal of medical research · 2013Article
- Effects of 17β-estradiol on proliferation, cell viability and intracellular redox status in native human lens epithelial cells.Molecular vision · 2011Article
- Effect of estrogen replacement therapy on lens epithelial cell apoptosis in an experimental rat model.International ophthalmology · 2010Article
- Regulation of lens gap junctions by Transforming Growth Factor beta.Molecular biology of the cell · 2010Article
- Glutathione and catalase suppress TGFbeta-induced cataract-related changes in cultured rat lenses and lens epithelial explants.Molecular vision · 2009Article
- Estrogen protects against radiation-induced cataractogenesis.Radiation research · 2008Article
- Mitochondrial superoxide dismutase activation with 17 beta-estradiol-treated human lens epithelial cells.Molecular vision · 2008Article
- Prevention of posterior capsular opacification through cyclooxygenase-2 inhibition.Molecular vision · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cataract, already a major cause of visual impairment and blindness, is likely to become an increasing problem as the world population ages. In a previous study, we showed that transforming growth factor-beta (TGFP) induces rat lenses in culture to develop opacities and other changes that have many features of human subcapsular cataracts. Here we show that estrogen protects against cataract. Lenses from female rats are more resistant to TGFbeta-induced cataract than those from males. Furthermore, lenses from ovariectomized females show increased sensitivity to the damaging effects of TGFbeta and estrogen replacement in vivo, or exposure to estrogen in vitro, restores resistance. Sex-dependent and estrogen-related differences in susceptibility to cataract formation, consistent with a protective role for estrogen, have been noted in some epidemiological studies. The present study in the rat indicates that estrogen provides protection against cataract by countering the damaging effects of TGFbeP. It also adds to an increasing body of evidence that hormone replacement therapy protects postmenopausal women against various diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.