ArticleThe Journal of experimental medicine1997
The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.
Article in The Journal of experimental medicine, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Promoter Proximity Defines Mutation Window for VJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- What Targets Somatic Hypermutation to the Immunoglobulin Loci?Viral immunology · 2020Review
- JMolecular immunology · 2018Article
- Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination.Microbiology spectrum · 2015Review
- RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome.Advances in immunology · 2015Review
- Article
- Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.PLoS biology · 2014Article
- Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Advances in immunology · 2014Review
- AID and Apobec3G haphazard deamination and mutational diversity.Cellular and molecular life sciences : CMLS · 2013Review
- Regulation of AID, the B-cell genome mutator.Genes & development · 2013Review
- AID targeting is dependent on RNA polymerase II pausing.Seminars in immunology · 2012Review
- Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications.Seminars in immunology · 2012Review
- Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.Advances in cancer research · 2012Review
- AID and somatic hypermutation.Advances in immunology · 2010Review
- A coming-of-age story: activation-induced cytidine deaminase turns 10.Nature immunology · 2009Review
- I. VH gene transcription creates stabilized secondary structures for coordinated mutagenesis during somatic hypermutation.Molecular immunology · 2008Article
- AID-mediated diversification within the IgL locus of chicken DT40 cells is restricted to the transcribed IgL gene.Molecular immunology · 2008Article
- Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias.Molecular immunology · 2007Article
- Article
- Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences.The Journal of experimental medicine · 2006Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
A somatic process introduces mutations into antibody variable (V) region genes at a high rate in many vertebrates, and is a major source of antibody diversity. The mechanism of this hypermutation process remains enigmatic, although retrospective studies and transgenic experiments have recently suggested a role for transcriptional regulatory elements. Here, we demonstrate that mouse heavy (H) chain loci in which the natural VH promoter has been replaced by a heterologous promoter undergo hypermutation. However, while the distribution of mutation in such loci appears normal, the frequency of mutation does not. Conversely, moving the VH promoter 750 bp upstream of its normal location results in a commensurate change in the site specificity of hypermutation in H chain loci, and the foreign DNA inserted into the VH leader intron to produce this promoter displacement is hypermutated in a manner indistinguishable from natural Ig DNA. These data establish a direct mechanistic link between the IgH transcription and hypermutation processes.
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