ArticleNeurochemical research1997
Effect of guanine nucleotides on [3H]glutamate binding and on adenylate cyclase activity in rat brain membranes.
Article in Neurochemical research, 1997. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Electrochemical investigation of the effect of some organic phosphates on haemoglobin.Journal of biosciences · 2007Article
- In vivo quinolinic acid increases synaptosomal glutamate release in rats: reversal by guanosine.Neurochemical research · 2005Article
- Neurotoxicity induced by glutamate in glucose-deprived rat hippocampal slices is prevented by GMP.Neurochemical research · 2005Article
- Characterization of imido [8-(3)H] guanosine 5'-triphosphate binding sites to rat brain membranes.Neurochemical research · 2004Article
- Interaction of adenosine and guanine derivatives in the rat hippocampus: effects on cyclic AMP levels and on the binding of adenosine analogues and GMP.Neurochemical research · 2000Article
- Compounds extracted from Phyllantus and Jatropha elliptica inhibit the binding of [3H]glutamate and [3H]GMP-PNP in rat cerebral cortex membrane.Neurochemical research · 2000Article
- Effects of lead on adenylate cyclase activity in rat cerebral cortex.Neurochemical research · 1999Article
- Study of adenosine A2 receptors in membrane preparations from optic tectum of chicks.Neurochemical research · 1999Article
- Effects of guanine nucleotides on glutamate-induced chemiluminescence in rat hippocampal slices submitted to hypoxia.Neurochemical research · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GMP-PNP, a non-hydrolyzable analog of GTP binds tightly to G-protein in the presence of Mg2+, so that the binding is stable even after exhaustive washings. This property was exploited to prepare membrane samples of rat brain where G-protein GTP-binding sites were saturated with GMP-PNP. Experiments carried out with these membranes showed that GTP, GMP-PNP, GDP-S and GMP (1 mM) inhibit the sodium-independent [3H]glutamate binding by 30-40% [F(4,40) = 5.9; p < .001], whereas only GMP-PNP activates adenylate cyclase activity [F(6,42) = 3.56; p < .01]. The inhibition of sodium-independent [3H]glutamate binding occurred in the absence of Mg2+. These findings suggest that guanine nucleotides may inhibit glutamate binding and activate adenylate cyclase through distinct mechanisms by acting on different sites.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.